Doppler ultrasound study of portal hemodynamics in patients with Gaucher disease
| Autor: | Dragan Tomic, Sladjana Dimitrijević, Vladimir Jurisic, Radmila Sarenac-Kovac, Mirjana Perišić |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
Enlarged liver business.industry portal flow velocity Hepatosplenomegaly Spleen Gaucher disease Hypoxia (medical) medicine.disease Gastroenterology General Biochemistry Genetics and Molecular Biology 3. Good health Doppler ultrasonography medicine.anatomical_structure lcsh:Biology (General) Internal medicine medicine Portal hypertension Bone marrow medicine.symptom General Agricultural and Biological Sciences business Perfusion Glucocerebrosidase lcsh:QH301-705.5 |
| Zdroj: | Archives of Biological Sciences, Vol 67, Iss 1, Pp 11-18 (2015) |
| ISSN: | 1821-4339 0354-4664 |
| Popis: | Gaucher disease is a lysosomal storage disorder caused by a deficiency of the enzyme glucocerebrosidase and characterized by the presence of pathological macrophages laden with glucosylceramide. Hepatosplenomegaly is a common manifestation of Gaucher disease, but symptomatic portal hypertension is rarely seen. The study included 20 untreated adult patients with Gaucher disease (non-neuronopathic type 1) diagnosed with the presence of Gaucher cells in the bone marrow, and 20 healthy subjects as controls. The examination of patients included color Doppler ultrasonography (pulsed Doppler mode), resistive index (RI) and Doppler perfusion index (DPI) using a Toshiba Xario ultrasound machine and a convex array probe PVT-375AX (1.9-6 MHz) with the objective of analyzing portal hemodynamics. Results showed that all patients had enlarged liver and spleen, and their average sizes were significantly larger than those in the healthy controls (liver: 17.04 vs.14.02 cm; spleen: 22.2 vs. 10.74 cm). DPI values were significantly different between patients and controls (0.15 vs. 0.21). Considering DPI |
| Databáze: | OpenAIRE |
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