Self-powered portable melt electrospinning for in situ wound dressing

Autor: Yuan Gao, Jiang-Jun Liu, Xiao-Fei Liu, Ying-Tao Zhao, Hong-Fei Xiang, Yun-Ze Long, Xiao-Xiong Wang, Jun Zhang
Rok vydání: 2020
Předmět:
Male
lcsh:Medical technology
Materials science
Biocompatibility
Cell Survival
Polyesters
lcsh:Biotechnology
Nanofibers
Biomedical Engineering
Pharmaceutical Science
Medicine (miscellaneous)
3D printing
Bioengineering
02 engineering and technology
010402 general chemistry
01 natural sciences
Applied Microbiology and Biotechnology
Rats
Sprague-Dawley
chemistry.chemical_compound
lcsh:TP248.13-248.65
Specific surface area
Animals
Composite material
Porosity
Melt electrospinning
Cells
Cultured
Electrospinning
business.industry
Research
Temperature
Electrochemical Techniques
Equipment Design
Fibroblasts
021001 nanoscience & nanotechnology
Bandages
Rats
0104 chemical sciences
lcsh:R855-855.5
chemistry
Hand-hold e-spinning gun
Wound dressing
Nanofiber
Polycaprolactone
Molecular Medicine
0210 nano-technology
business
Zdroj: Journal of Nanobiotechnology, Vol 18, Iss 1, Pp 1-10 (2020)
Journal of Nanobiotechnology
ISSN: 1477-3155
Popis: Background Electrospun (e-spun) nanofibers for wound dressing have attracted wide attention due to its large specific surface area, large porosity and breathability. Compared with solution electrospinning (e-spinning), melt e-spinning is more bio-friendly without toxic solvent participation, which provides the possibility of in situ e-spinning on wounds directly. However, previously reported melt e-spinning devices were usually bulky and cumbersome due to their necessary heating unit, and different components were separated to avoid electrostatic interference. Results In this article, we report on a self-powered hand-held melt e-spinning gun which can work without any external power supply (outdoors). The problem of electrostatic interference for this integrated device was solved by using a special high heat transfer insulation unit. The apparatus is easy and safe to operate by a single hand due to its small volume (24 × 6 × 13 cm3) and light weight (about 450 g). Some biodegradable polymers, for example, polycaprolactone (PCL) fibers were successful e-spun onto wounds directly by using this dressing gun. Conclusions PCL fibrous membrane has good biocompatibility and can be in situ electrospun to wound surface as a wound dressing by the portable melt e-spinning gun. Besides wound dressing, this hand-held melt e-spinning gun may be used in 3D printing and experimental teaching demonstration aids.
Databáze: OpenAIRE
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