Self-powered portable melt electrospinning for in situ wound dressing
Autor: | Yuan Gao, Jiang-Jun Liu, Xiao-Fei Liu, Ying-Tao Zhao, Hong-Fei Xiang, Yun-Ze Long, Xiao-Xiong Wang, Jun Zhang |
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Rok vydání: | 2020 |
Předmět: |
Male
lcsh:Medical technology Materials science Biocompatibility Cell Survival Polyesters lcsh:Biotechnology Nanofibers Biomedical Engineering Pharmaceutical Science Medicine (miscellaneous) 3D printing Bioengineering 02 engineering and technology 010402 general chemistry 01 natural sciences Applied Microbiology and Biotechnology Rats Sprague-Dawley chemistry.chemical_compound lcsh:TP248.13-248.65 Specific surface area Animals Composite material Porosity Melt electrospinning Cells Cultured Electrospinning business.industry Research Temperature Electrochemical Techniques Equipment Design Fibroblasts 021001 nanoscience & nanotechnology Bandages Rats 0104 chemical sciences lcsh:R855-855.5 chemistry Hand-hold e-spinning gun Wound dressing Nanofiber Polycaprolactone Molecular Medicine 0210 nano-technology business |
Zdroj: | Journal of Nanobiotechnology, Vol 18, Iss 1, Pp 1-10 (2020) Journal of Nanobiotechnology |
ISSN: | 1477-3155 |
Popis: | Background Electrospun (e-spun) nanofibers for wound dressing have attracted wide attention due to its large specific surface area, large porosity and breathability. Compared with solution electrospinning (e-spinning), melt e-spinning is more bio-friendly without toxic solvent participation, which provides the possibility of in situ e-spinning on wounds directly. However, previously reported melt e-spinning devices were usually bulky and cumbersome due to their necessary heating unit, and different components were separated to avoid electrostatic interference. Results In this article, we report on a self-powered hand-held melt e-spinning gun which can work without any external power supply (outdoors). The problem of electrostatic interference for this integrated device was solved by using a special high heat transfer insulation unit. The apparatus is easy and safe to operate by a single hand due to its small volume (24 × 6 × 13 cm3) and light weight (about 450 g). Some biodegradable polymers, for example, polycaprolactone (PCL) fibers were successful e-spun onto wounds directly by using this dressing gun. Conclusions PCL fibrous membrane has good biocompatibility and can be in situ electrospun to wound surface as a wound dressing by the portable melt e-spinning gun. Besides wound dressing, this hand-held melt e-spinning gun may be used in 3D printing and experimental teaching demonstration aids. |
Databáze: | OpenAIRE |
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