Impaired Fibrous Repair
| Autor: | Ana Persson, Andreas Edsfeldt, Pontus Dunér, Harry Björkbacka, Olle Melander, Helena Grufman, Jan Nilsson, Marie Mn Nilsson, Eva Bengtsson, Mihaela Nitulescu, Marju Orho-Melander, Isabel Gonçalves, Inês G. Mollet |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Carotid Artery Diseases
Male Risk Pathology medicine.medical_specialty medicine.medical_treatment Inflammation Carotid endarterectomy Extracellular matrix Diabetes mellitus medicine Humans Hypoglycemic Agents Stroke Antihypertensive Agents Aged Platelet-Derived Growth Factor Endarterectomy Carotid Extracellular Matrix Proteins Principal Component Analysis Rupture Spontaneous biology business.industry Growth factor Tissue Inhibitor of Metalloproteinases Middle Aged medicine.disease Fibrosis Matrix Metalloproteinases Metformin Plaque Atherosclerotic Diabetes Mellitus Type 2 biology.protein Cytokines Immunohistochemistry Female Disease Susceptibility Hydroxymethylglutaryl-CoA Reductase Inhibitors medicine.symptom Cardiology and Cardiovascular Medicine business Elastin |
| Zdroj: | Arteriosclerosis, Thrombosis, and Vascular Biology. 34:2143-2150 |
| ISSN: | 1524-4636 1079-5642 |
| DOI: | 10.1161/atvbaha.114.303414 |
| Popis: | Objective— Diabetes mellitus (DM) type II is increasing rapidly worldwide. Patients with DM II have a greater atherosclerotic burden and higher risk of developing cardiovascular complications. Inflammation has been proposed as the main cause for the high risk of atherosclerotic disease in DM II. In this study, we compared markers of inflammation and fibrous repair in plaques from subjects with and without DM II. Approach and Results— Carotid endarterectomy specimens were obtained from 63 patients with and 131 without DM. Plaque structure, connective tissue proteins, inflammatory cells, and markers were analyzed by immunohistochemistry, ELISA, Mesoscale, and Luminex technology. Carotid plaques from diabetics had lower levels of extracellular matrix proteins, elastin, and collagen, which are critical for plaque stability. Plaques from diabetics had reduced levels of platelet-derived growth factor and matrix metalloproteinase-2, both important for tissue repair. No differences were observed in inflammatory markers in plaques from diabetic and nondiabetic patients. Conclusion— This study suggests that atherosclerotic plaques in subjects with DM II are more prone to rupture because of impaired repair responses rather than to increased vascular inflammation. Although this study did not have a mechanistic design, our findings suggest that targeting impaired repair responses in carotid plaques may help to increase our understanding of atherosclerotic plaque development and vulnerability in patients with DM II. |
| Databáze: | OpenAIRE |
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