Giant abdominopelvic epithelioid angiomyolipoma associated with tuberous sclerosis: Report of a case

Autor: Zeri Kp, Giorgio Di Matteo, A Marzullo, Domenico Mascagni, Nadia Peparini, Alessandro Maturo, Bianca Martin Wedard, Filippo Maria Di Matteo
Rok vydání: 1999
Předmět:
Zdroj: ResearcherID
ISSN: 1436-2813
0941-1291
DOI: 10.1007/bf02482270
Popis: Tuberous sclerosis is a hereditary autosomal-dominant disease characterized by hamartomas that can develop in any organ. We report herein the case of a 34-year-old female with tuberous sclerosis and a huge abdominopelvic mass that started growing quickly 2 years after its diagnosis. The patient had undergone several previous operations for hydrocephalus and cerebral tubers, and a nephrectomy for right renal angiomyolipoma. On admission, she was in poor general health with renal failure, severe anemia, and weight loss. A laparotomy revealed that the tumor occupied the pelvis, the lower and part of the upper abdomen, and was hypervascularized, with an extremely irregular surface covered in nodules, vegetations, and areas of hemorrhagic necrosis. The development of the mass and the impossibility of recognizing the internal genital organs led us to assume that the formation had originated from these. Frozen-section examination indicated an undifferentiated tumor that had not been completely resected. Her postoperative course was complicated by bronchopneumonia and progressive renal failure. The patient died 10 days after surgery due to cardio-respiratory failure. A histological diagnosis of epithelioid angiomyolipoma was confirmed. Although it is presently impossible to determine whether angiomyolipoma with predominant epithelioid cells is more aggressive than typical angiomyolipoma, it definitively demonstrated local aggressive behavior in this patient.
Databáze: OpenAIRE
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