An Overview of Basic Molecular Biology of SARS-CoV-2 and Current COVID-19 Prevention Strategies
| Autor: | Khaleda Begum, Raja Ahmed, Suraiya Akhtar, Sofia Banu, Ankur Das |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
MARS-CoV
Middle East respiratory syndrome coronavirus 0301 basic medicine GM-CSF Macrophage colony-stimulating factor Coronavirus disease 2019 (COVID-19) Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viruses CDC Centres for Disease Control and Prevention Biology medicine.disease_cause Genome organization and expression Genome Article SARS-CoV2 severe acute respiratory syndrome coronavirus 2 HCV Hepatitis C virus HIV Human immune deficiency virus 03 medical and health sciences 0302 clinical medicine LAMP Loop mediated Isothermal Amplification Genetics medicine Furin Coronavirus COVID-19 coronavirus diseases CD4 and CD8 Cluster of differentiation SARS-CoV-2 fungi virus diseases RNA Spike Protein Molecular biology virology 030104 developmental biology 030220 oncology & carcinogenesis biology.protein Prevention strategies Identification (biology) WHO World Health Organisation AEC2 Angiotensin- converting enzyme 2 |
| Zdroj: | Gene Reports |
| Popis: | Coronavirus Disease 2019 (COVID-19) manifests as extreme acute respiratory conditions caused by a novel beta coronavirus named severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) which is reported to be the seventh coronavirus to infect humans. Like other SARS-CoVs it has a large positive-stranded RNA genome. But, specific furin site in the spike protein, mutation prone and phylogenetically mess open reading frame1ab (Orf1ab) separates SARS-CoV-2 from other RNA viruses. Since the outbreak (February - March 2020), researchers, scientists, and medical professionals are inspecting all possible facts from every possible aspect including its replication, detection, and prevention strategies. This led to the prompt identification of its basic biology, genome characterization, structural and expression based functional information of proteins, and utilization of this information in optimizing strategies to prevent its spread. This review summarizes the recent updates on the basic molecular biology of SARS-CoV-2 and prevention strategies undertaken worldwide to tackle COVID-19. This recent information can be implemented for the development and designing of therapeutics against SARS-CoV-2. |
| Databáze: | OpenAIRE |
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