A novel nutritional supplement containing amino acids and chromium decreases postprandial glucose response in a randomized, double-blind, placebo-controlled study
| Autor: | Rickard Öste, Azat Samigullin, Elin Östman, Kristina E. Andersson, Lovisa Heyman-Lindén, Inger Björck, Per M. Humpert |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Chromium
Male Physiology 030204 cardiovascular system & hematology Cardiovascular Medicine Gastroenterology Biochemistry Placebos 0302 clinical medicine Endocrinology Medicine and Health Sciences Glucose homeostasis Insulin Amino Acids education.field_of_study Multidisciplinary Organic Compounds Monosaccharides Venous blood Middle Aged Postprandial Period Blood Sugar Body Fluids Type 2 Diabetes Chemistry Postprandial Blood Cardiovascular Diseases Physical Sciences Medicine Female Anatomy Research Article Chemical Elements Adult medicine.medical_specialty Adolescent Endocrine Disorders Science Population Cmax Carbohydrates Blood sugar 030209 endocrinology & metabolism 03 medical and health sciences Young Adult Double-Blind Method Internal medicine Diabetes mellitus medicine Diabetes Mellitus Humans education Diabetic Endocrinology business.industry Organic Chemistry Chemical Compounds Biology and Life Sciences Nutritional Supplement Drink medicine.disease Hormones Capillaries Glucose Metabolic Disorders Dietary Supplements Cardiovascular Anatomy Blood Vessels business |
| Zdroj: | PLoS ONE PLoS ONE, Vol 15, Iss 6, p e0234237 (2020) |
| ISSN: | 1932-6203 |
| Popis: | High postprandial blood glucose levels are associated with increased mortality, cardiovascular events and development of diabetes in the general population. Interventions targeting postprandial glucose have been shown to prevent both cardiovascular events and diabetes. This study evaluates the efficacy and safety of a novel nutritional supplement targeting postprandial glucose excursions in non-diabetic adults. Sixty overweight healthy male and female participants were recruited at two centers and randomized in a double-blind, placebo-controlled, crossover design. The supplement, a water-based drink containing 2.6g of amino acids (L-Leucine, L-Threonine, L-Lysine Monohydrochloride, L-Isoleucine, L-Valine) and 250 mcg of chromium picolinate, was consumed with a standardized carbohydrate-rich meal. The primary endpoint was the incremental area under the curve (iAUC) for venous blood glucose from 0 to 120 minutes. Secondary endpoints included glucose iAUC 0-180 minutes and the maximum glucose concentration (Cmax), for both venous and capillary blood glucose. In the intention-to-treat-analysis (n = 60) the supplement resulted in a decreased venous blood glucose iAUC0-120min compared to placebo, mean (SE) of 68.7 (6.6) versus 52.2 (6.8) respectively, a difference of -16.5 mmol/L•min (95% CI -3.1 to -30.0, p = 0.017). The Cmax for venous blood glucose for the supplement and placebo were 6.45 (0.12) versus 6.10 ( |
| Databáze: | OpenAIRE |
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