Phase Angle and Nutritional Status: The Impact on Survival and Health-Related Quality of Life in Locally Advanced Uterine Cervical Cancer

Autor: Faviola González-Barba, Luz-Ma.-Adriana Balderas-Peña, Benjamín Trujillo-Hernández, Luz-María Cervantes-González, Javier-Andrés González-Rodríguez, Leonardo-Xicotencatl Gutiérrez-Rodríguez, Adriana Alvarado-Zermeño, Aldo-Antonio Alcaraz-Wong, Eduardo Gómez-Sánchez, Gabriela-Guadalupe Carrillo-Núñez, Mario Salazar-Páramo, Arnulfo-Hernán Nava-Zavala, Benjamín Rubio-Jurado, Mario-Alberto Mireles-Ramírez, Brenda-Eugenia Martínez-Herrera, Daniel Sat-Muñoz
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Healthcare; Volume 11; Issue 2; Pages: 246
ISSN: 2227-9032
DOI: 10.3390/healthcare11020246
Popis: The phase angle, an indicator of muscle mass status and membrane cell integrity, has been associated with low survival, poorer clinical outcomes, and worse quality of life among cancer patients, but information on women with uterine cervical cancer (UCCa) is scarce. In this prospective study, we used a bioelectrical impedance analyzer to obtain the PA of 65 women with UCCa. We compared the health-related quality of life and inflammatory and nutritional indicators between low PA and normal PA. The mean age was 52 ± 13. The low PA and normal PA groups differed in terms of the C-reactive protein (15.8 ± 19.6 versus 6.82 ± 5.02, p = 0.022), glucose (125.39 ± 88.19 versus 88.78 ± 23.08, p = 0.021), albumin (3.9 ± 0.39 versus 4.37 ± 0.30, p = 0.000), EORTC QLQ-C30 loss of appetite symptom scale score (33.33 (0.0–100.00) versus 0.0 (0.0–0.0), p = 0.005), and EORTC QLQ-CX24 menopausal symptoms scale score (0.0 (0.0–33.33) versus 0.0 (0.0–100.0), p = 0.03). The main finding of the present study is the interaction between PA and obesity as critical cofactors in the UCCa adeno and adenosquamous histologic variants, to a greater extent than cervical squamous cell carcinoma.
Databáze: OpenAIRE