The neural circuitry underlying the 'rhythm effect' in stuttering
| Autor: | Jason A. Tourville, Elizabeth S. Heller Murray, Saul A. Frankford, Frank H. Guenther, Alfonso Nieto-Castanon, Matthew Masapollo, Shanqing Cai |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Linguistics and Language medicine.medical_specialty Stuttering media_common.quotation_subject Sensory system Audiology 050105 experimental psychology Language and Linguistics 03 medical and health sciences Speech and Hearing Fluency 0302 clinical medicine Rhythm Speech Production Measurement Perception medicine Humans Speech 0501 psychology and cognitive sciences Prefrontal cortex media_common Language Auditory feedback medicine.diagnostic_test 05 social sciences Motor control nervous system diseases Reading Orbitofrontal cortex Special Issue: Selected Papers From the 2020 Conference on Motor Speech—Basic Science and Clinical Innovation medicine.symptom Psychology Functional magnetic resonance imaging 030217 neurology & neurosurgery |
| Zdroj: | J Speech Lang Hear Res |
| DOI: | 10.1101/2020.10.27.350975 |
| Popis: | PurposeStuttering is characterized by intermittent speech disfluencies, which are dramatically reduced when speakers synchronize their speech with a steady beat. The goal of this study was to characterize the neural underpinnings of this phenomenon using functional magnetic resonance imaging.MethodData were collected from 16 adults who stutter and 17 adults who do not stutter while they read sentences aloud either in a normal, self-paced fashion or paced by the beat of a series of isochronous tones (“rhythmic”). Task activation and task-based functional connectivity analyses were carried out to compare neural responses between speaking conditions and groups after controlling for speaking rate.ResultsAdults who stutter produced fewer disfluent trials in the rhythmic condition than in the normal condition. Adults who stutter did not have any significant changes in activation between the rhythmic condition and the normal condition, but when groups were collapsed, participants had greater activation in the rhythmic condition in regions associated with speech sequencing, sensory feedback control, and timing perception. Adults who stutter also demonstrated increased functional connectivity among cerebellar regions during rhythmic speech as compared to normal speech and decreased connectivity between the left inferior cerebellum and the left prefrontal cortex.ConclusionsModulation of connectivity in the cerebellum and prefrontal cortex during rhythmic speech suggests that this fluency-inducing technique activates a compensatory timing system in the cerebellum and potentially modulates top-down motor control and attentional systems. These findings corroborate previous work associating the cerebellum with fluency in adults who stutter and indicate that the cerebellum may be targeted to enhance future therapeutic interventions.Supplemental Materialhttps://doi.org/10.23641/asha.14417681 |
| Databáze: | OpenAIRE |
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