Supplementary Figures 1 - 5 from Combination of 4-1BB Agonist and PD-1 Antagonist Promotes Antitumor Effector/Memory CD8 T Cells in a Poorly Immunogenic Tumor Model

Autor: John C. Lin, Todd VanArsdale, Mengli Xiong, Chi Ying, Hui Wang, Xiaoai Li, Konstantinos Tsaparikos, Guang Huan Tu, Kathryn Logronio, Winston Evering, Mark Elliott, Bart Jessen, Timothy S. Fisher, Li-Fen Lee, Shihao Chen
Rok vydání: 2023
DOI: 10.1158/2326-6066.22537411.v1
Popis: Supplementary Figure S1. Anti-4-1BB and anti-PD-1 synergized to suppress B16F10 tumor growth. Supplementary Figure S2. The flow cytometric gating strategy to analyze immune cells. Supplementary Figure S3. Elevated expression of genes associated with anti-tumor immune response in MC38 colon carcinomas. Supplementary Figure S4. Accumulation of CD8+ T cell and memory phenotype differentiation in MC38 model. Supplementary Figure S5. Serum liver enzyme levels and hematology alterations in response to 4-1BB activation therapy in B16F10 tumor-bearing mice.
Databáze: OpenAIRE