Fetal brain development in small-for-gestational age (SGA) fetuses and normal controls
| Autor: | Elena Jacob, Kerstin Hammer, Ralf Schmitz, Mareike Möllers, Helen Ann Köster, Janina Braun, Kathrin Oelmeier, Walter Klockenbusch, Maria Karina Falkenberg |
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| Rok vydání: | 2019 |
| Předmět: |
Fetus
030219 obstetrics & reproductive medicine Brain development business.industry Ultrasound Obstetrics and Gynecology Cisterna magna medicine.disease Cavum septi pellucidi Fetal brain 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure Ventricle Pediatrics Perinatology and Child Health medicine Small for gestational age business Nuclear medicine 030217 neurology & neurosurgery |
| Zdroj: | Journal of perinatal medicine. |
| ISSN: | 1619-3997 |
| Popis: | ObjectiveTo assess whether fetal brain structures routinely measured during the second and third trimester ultrasound scans, particularly the width of the cavum septi pellucidi (CSP), differ between fetuses small for gestational age (SGA), fetuses very small for gestational age (VSGA) and normal controls.MethodsIn this retrospective study, we examined standard ultrasound measurements of 116 VSGA, 131 SGA fetuses and 136 normal controls including the head circumference (HC), transversal diameter of the cerebellum (TCD), the sizes of the lateral ventricle (LV) and the cisterna magna (CM) from the second and third trimester ultrasound scans extracted from a clinical database. We measured the CSP in these archived ultrasound scans. The HC/CSP, HC/LV, HC/CM and HC/TCD ratios were calculated as relative values independent of the fetal size.ResultsThe HC/CSP ratio differed notably between the controls and each of the other groups (VSGA P = 0.018 and SGA P = 0.017). No notable difference in the HC/CSP ratio between the VSGA and SGA groups could be found (P = 0.960). The HC/LV, HC/CM and HC/TCD ratios were similar in all the three groups.ConclusionRelative to HC, the CSP is larger in VSGA and SGA fetuses than in normal controls. However, there is no notable difference between VSGA and SGA fetuses, which might be an indicator for abnormal brain development in this group. |
| Databáze: | OpenAIRE |
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