Novel gammaherpesvirus associated with primary gastric T‐cell lymphoma in a free‐ranging giant armadillo in Brazil
| Autor: | Débora Regina Yogui, Bruno Cogliati, Arnaud Leonard Jean Desbiez, Danilo Kluyber, Josué Díaz-Delgado, Gislaine Taimara Dalazen, Rodrigo Albergaria Réssio, Tereza Cristina da Silva, José Luiz Catão-Dias, Pedro Enrique Navas-Suárez, Juliana Mariotti Guerra, Natália Coelho Couto de Azevedo Fernandes, Carlos Sacristán, Amanda Carolina Alves |
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| Rok vydání: | 2021 |
| Předmět: |
Armadillos
Epstein-Barr Virus Infections Herpesvirus 4 Human 040301 veterinary sciences LINFOMA Lymphoma T-Cell Virus 0403 veterinary science 03 medical and health sciences Gammaherpesvirinae Cingulata biology.animal medicine Animals Pathogen 030304 developmental biology 0303 health sciences General Veterinary General Immunology and Microbiology biology Outbreak Xenarthra 04 agricultural and veterinary sciences General Medicine biology.organism_classification medicine.disease Virology Lymphoma Novel virus Armadillo Brazil |
| Zdroj: | Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
| ISSN: | 1865-1682 1865-1674 |
| DOI: | 10.1111/tbed.14189 |
| Popis: | The number of viral-associated neoplasms reported in wildlife has increased over the last decades, likely because of growing research efforts and a potentially greater burden of carcinogenic pathogens. Herein, we describe a primary gastric T-cell lymphoma in one free-ranging giant armadillo (Priodontes maximus) from Brazilian Pantanal infected by a novel gammaherpesvirus, proposed as Cingulatid gammaherpesvirus 1 (CiHV-1). By chromogenic in situ hybridisation against Epstein-Barr virus some neoplastic cells were labeled. Subsequently, a molecular screening was carried out to detect the occurrence of this pathogen in other giant armadillos in the same region. Overall, this novel virus was detected in 14.3% (3/21) of the tested giant armadillos. We suggest this herpesvirus, the first in Xenarthra, as a plausible aetiology of the neoplasm. The implications of CiHV-1 for this species are uncertain; while no outbreaks of disease have been recorded, the present study raises concerns. Further research is warranted to assess the real significance of CiHV-1 and its potential oncogenic role in this species. |
| Databáze: | OpenAIRE |
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