Human Amniotic Epithelial Cells Secretome: Components, Bioactivity, and Challenges

Autor:	Toshio Miki, Ibrahim Fathi
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	Medicine (General) secretome R5-920 paracrine human amniotic epithelial cells (hAECs) cardiovascular system Medicine conditioned media (CM) cell-free therapeutics General Medicine Review exosomes
Zdroj:	Frontiers in Medicine Frontiers in Medicine, Vol 8 (2022)
ISSN:	2296-858X
Popis:	Human amniotic epithelial cells (hAECs) derived from placental tissue have received significant attention as a promising tool in regenerative medicine. Several studies demonstrated their anti-inflammatory, anti-fibrotic, and tissue repair potentials. These effects were further shown to be retained in the conditioned medium of hAECs, suggesting their paracrine nature. The concept of utilizing the hAEC-secretome has thus evolved as a therapeutic cell-free option. In this article, we review the different components and constituents of hAEC-secretome and their influence as demonstrated through experimental studies in the current literature. Studies examining the effects of conditioned medium, exosomes, and micro-RNA (miRNA) derived from hAECs are included in this review. The challenges facing the application of this cell-free approach will also be discussed based on the current evidence.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81fe987efbe35a3dc4b1378a221e433a http://europepmc.org/articles/PMC8784524 Zobrazit plný text záznamu