Elevated plasma homocysteine in acute stroke was not associated with severity and outcome: stronger association with small artery disease
| Autor: | R. L’Erario, G. Bader, C. Azzini, F. Bortolon, M. Morra, Giuseppe Billo, Elisabetta Galloni, E. Arzenton, I. Bolgan, P. Parisen, F. Perini, V. Toso, P. G. Garofalo, L. Bartolomei, G. Stenta, S. Alba, R. Ruffini, P. Dudine |
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| Rok vydání: | 2005 |
| Předmět: |
Adult
Male medicine.medical_specialty Neurology Homocysteine Dermatology Severity of Illness Index chemistry.chemical_compound Risk Factors Internal medicine Severity of illness medicine Odds Ratio Humans cardiovascular diseases Stroke Neuroradiology Aged business.industry Case-control study General Medicine Odds ratio Middle Aged medicine.disease Psychiatry and Mental health chemistry Quartile Case-Control Studies Multivariate Analysis Cardiology Physical therapy Regression Analysis Female Neurology (clinical) Cerebral Arterial Diseases business |
| Zdroj: | Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. 26(5) |
| ISSN: | 1590-1874 |
| Popis: | Homocysteine increases in the acute phase of ischaemic stroke and from the acute to the convalescent phase, suggesting that hyper-homocysteinaemia may be a consequence rather than a causal factor. Therefore we measured homocysteine plasma levels in stroke patients in order to investigate possible correlations of homocysteine with stroke severity and clinical outcome. Further we looked for eventual differences in stroke subtypes. We prospectively studied plasma homocysteine levels in acute stroke patients admitted to the stroke unit of our department. Seven hundred and seventy-five ischaemic stroke patients, 39 cerebral haemorrhages and 421 healthy control subjects have been enrolled. Stroke severity and clinical outcome were measured with the Scandinavian Stroke Scale, the Rankin Scale and the Barthel Index. Stroke severity by linear stepwise regression analysis was not an independent determinant of plasma homocysteine levels. Homocysteine was not correlated with outcome measured by the Barthel Index. Mean plasma homocysteine of both ischaemic and haemorrhagic stroke was significantly higher than controls (p |
| Databáze: | OpenAIRE |
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