Air Pollution–Associated Changes in Lung Function among Asthmatic Children in Detroit
| Autor: | Fuyuen Y. Yip, Yolanda Hill, Toby C. Lewis, Graciela Mentz, Gerald J. Keeler, J. Timothy Dvonch, Xihong Lin, Barbara A. Israel, Edith A. Parker, Thomas G. Robins, Linda Gonzalez |
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| Rok vydání: | 2005 |
| Předmět: |
Male
Michigan Pediatrics Urban Population Health Toxicology and Mutagenesis air pollution Air pollution Peak Expiratory Flow Rate 010501 environmental sciences medicine.disease_cause 01 natural sciences 0302 clinical medicine Adrenal Cortex Hormones Forced Expiratory Volume Detroit Child Respiratory Tract Infections Generalized estimating equation Lung function community-based participatory research Air Pollutants Respiratory tract infections Respiratory infection Dust National Ambient Air Quality Standards 3. Good health Epidemiological Monitoring Children's Health Female Environmental Monitoring medicine.medical_specialty Models Biological 03 medical and health sciences Ozone medicine Humans Particle Size 0105 earth and related environmental sciences Asthma particulate matter Pollutant business.industry Research Public Health Environmental and Occupational Health lung function asthma medicine.disease 030228 respiratory system business Demography |
| Zdroj: | Environmental Health Perspectives |
| ISSN: | 1552-9924 0091-6765 |
| DOI: | 10.1289/ehp.7533 |
| Popis: | In a longitudinal cohort study of primary-school-age children with asthma in Detroit, Michigan, we examined relationships between lung function and ambient levels of particulate matteror = 10 microm andor = 2.5 microm in diameter (PM10 and PM2.5) and ozone at varying lag intervals using generalized estimating equations. Models considered effect modification by maintenance corticosteroid (CS) use and by the presence of an upper respiratory infection (URI) as recorded in a daily diary among 86 children who participated in six 2-week seasonal assessments from winter 2001 through spring 2002. Participants were predominantly African American from families with low income, and75% were categorized as having persistent asthma. In both single-pollutant and two-pollutant models, many regressions demonstrated associations between higher exposure to ambient pollutants and poorer lung function (increased diurnal variability and decreased lowest daily values for forced expiratory volume in 1 sec) among children using CSs but not among those not using CSs, and among children reporting URI symptoms but not among those who did not report URIs. Our findings suggest that levels of air pollutants in Detroit, which are above the current National Ambient Air Quality Standards, adversely affect lung function of susceptible asthmatic children. |
| Databáze: | OpenAIRE |
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