Intratumoural FOXP3-positive regulatory T cells are associated with adverse prognosis in radically resected gastric cancer
| Autor: | Mauro Magnani, Daniele Santini, Cathie Spino, Francesco Graziano, Carla Rabitti, Valerio Sisti, Vincenzo Catalano, Paolo Alessandroni, Pietro Muretto, Giuseppe Tonini, Costantino Zingaretti, Andrea Cicetti, Paolo Giordani, Pier Adelchi Ruffini, Giuseppe Perrone, Sergio Morini, Annamaria Ruzzo, Chiara Spoto, S. Demidio |
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| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Pathology FOXP3 T regulatory cells Perineural invasion chemical and pharmacologic phenomena Kaplan-Meier Estimate Adenocarcinoma Gastroenterology T-Lymphocytes Regulatory Gastrectomy Stomach Neoplasms Internal medicine Antineoplastic Combined Chemotherapy Protocols Medicine Humans Clinical significance Stomach cancer Grading (tumors) Aged Retrospective Studies Aged 80 and over business.industry gastric cancer tumour immunology Cancer hemic and immune systems Forkhead Transcription Factors Middle Aged medicine.disease Prognosis Immunohistochemistry Lymphatic system Oncology prognosis Female Neoplasm Recurrence Local business |
| Popis: | We investigated the clinical significance of tumour-infiltrating FOXP3-positive regulatory T cells (Tregs) in radically resected (R0) gastric cancer. From a single-institution database, tumors of 110 patients who underwent R0 resection for stage II-III disease were studied for FOXP3-positive Tregs by immunohistochemistry. The observed median number of FOXP3-positive Tregs was used as the cut-point in analyses (6 versusor=6 count). Tregs were significantly higher in gastric carcinomas than in normal tissue (P = 0.0001). Tregs countor=6 was significantly associated with vascular/lymphatic/perineural invasion (VELIPI) in the tumour (P = 0.03). Multivariate analysis showed association between adverse relapse-free survival and grading 3, stage III, VELIPI and Tregs countor=6 (P = 0.02). Adverse overall survival was associated with grading 3, stage III, VELIPI and Tregs countor=6 (P = 0.006). FOXP3-positive Tregs may be a novel marker for identifying high-risk gastric cancer patients. Present findings deserve additional investigation as Tregs may also represent an innovative therapeutic target. |
| Databáze: | OpenAIRE |
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