The Biochemical and Genetic Basis for the Biosynthesis of Bioactive Compounds in Hypericum Perforatum L., One of the Largest Medicinal Crops in Europe
| Autor: | Paride Rizzo, John C. D’Auria, Beena M Ravindran, Lothar Altschmied, Twan Rutten |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Hypericum perforatum
dark glands lcsh:QH426-470 Phytochemicals Phloroglucinol Antineoplastic Agents Review Biology chemistry.chemical_compound Biosynthesis pale glands Genetics hyperforin Humans Perylene Genetics (clinical) Plant Proteins Pharmaceutical industry Anthracenes Traditional medicine Plant Extracts Terpenes business.industry Anticancer drug Antidepressive Agents Hypericin Europe Saint john's wort Hyperforin lcsh:Genetics chemistry Saint John’s Wort biosynthesis hypericin business Hypericum |
| Zdroj: | Genes, Vol 11, Iss 1210, p 1210 (2020) Genes |
| ISSN: | 2073-4425 |
| Popis: | Hypericum perforatum L. commonly known as Saint John’s Wort (SJW), is an important medicinal plant that has been used for more than 2000 years. Although H. perforatum produces several bioactive compounds, its importance is mainly linked to two molecules highly relevant for the pharmaceutical industry: the prenylated phloroglucinol hyperforin and the naphtodianthrone hypericin. The first functions as a natural antidepressant while the second is regarded as a powerful anticancer drug and as a useful compound for the treatment of Alzheimer’s disease. While the antidepressant activity of SJW extracts motivate a multi-billion dollar industry around the world, the scientific interest centers around the biosynthetic pathways of hyperforin and hypericin and their medical applications. Here, we focus on what is known about these processes and evaluate the possibilities of combining state of the art omics, genome editing, and synthetic biology to unlock applications that would be of great value for the pharmaceutical and medical industries. |
| Databáze: | OpenAIRE |
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