Interactions Between KIR3DS1 and HLA-F Activate Natural Killer Cells to Control HCV Replication in Cell Culture
| Autor: | Marcus Altfeld, Christian Körner, Annerose E. Ziegler, Tobias Poch, Maura Dandri, Christoph Schramm, Eva Herker, Laura Richert, Gloria Martrus, Julian Schulze zur Wiesch, Sebastian Lunemann, J Kah, Angelique Hölzemer, Leonard U. Hess, Pia Fittje, Wilfredo F. Garcia-Beltran, Karl J. Oldhafer, Annika E. Langeneckert, Anja Schöbel |
|---|---|
| Přispěvatelé: | Heinrich Pette Institute [Hamburg], Universitaetsklinikum Hamburg-Eppendorf = University Medical Center Hamburg-Eppendorf [Hamburg] (UKE), Ragon Institute of MGH, MIT and Harvard, Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Statistics In System biology and Translational Medicine (SISTM), Inria Bordeaux - Sud-Ouest, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)- Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Bordeaux [Bordeaux], Université de Bordeaux (UB), Semmelweis University of Medicine [Budapest] |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Receptors KIR3DS1 Hepatitis C virus Killer-cell immunoglobulin-like receptor Hepacivirus Human leukocyte antigen Biology Lymphocyte Activation Virus Replication medicine.disease_cause Natural killer cell 03 medical and health sciences 0302 clinical medicine Immune system medicine Humans Receptor Cells Cultured Hepatology Histocompatibility Antigens Class I Gastroenterology Immunity Hepatitis C Virology 3. Good health Killer Cells Natural 030104 developmental biology medicine.anatomical_structure Viral replication Cell culture [SDV.IMM]Life Sciences [q-bio]/Immunology 030215 immunology Regulation Anti-viral immune response |
| Zdroj: | Gastroenterology Gastroenterology, WB Saunders, 2018, ⟨10.1053/j.gastro.2018.07.019⟩ Gastroenterology, 2018, ⟨10.1053/j.gastro.2018.07.019⟩ |
| ISSN: | 0016-5085 1528-0012 |
| DOI: | 10.1053/j.gastro.2018.07.019⟩ |
| Popis: | International audience; Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer (NK) cells. Binding of KIR3DS1 to its recently discovered ligand, HLA-F, activates NK cells and has been associated with resolution of hepatitis C virus (HCV) infection. We investigated the mechanisms by which KIR3DS1 contributes to the antiviral immune response. Using cell culture systems, mice with humanized livers , and primary liver tissue from HCV-infected individuals, we found that the KIR3DS1 ligand HLA-F is upregulated on HCV-infected cells, and that interactions between KIR3DS1 and HLA-F contribute to NK cell-mediated control of HCV. Strategies to promote interaction between KIR3DS1 and HLA-F might be developed for treatment of infectious diseases and cancer. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|