Value of peripheral neurotrophin levels for the diagnosis of depression and response to treatment: A systematic review and meta-analysis

Autor: Zhijun Zhang, Ruize Song, Yachen Shi, Di Luan
Rok vydání: 2020
Předmět:
Vascular Endothelial Growth Factor A
Oncology
medicine.medical_specialty
S100 Calcium Binding Protein beta Subunit
03 medical and health sciences
0302 clinical medicine
Neurotrophic factors
Internal medicine
Nerve Growth Factor
medicine
Glial cell line-derived neurotrophic factor
Humans
Pharmacology (medical)
Nerve Growth Factors
Insulin-Like Growth Factor I
Biological Psychiatry
Pharmacology
Depressive Disorder
Major
biology
business.industry
Brain-Derived Neurotrophic Factor
medicine.disease
Antidepressive Agents
Pathophysiology
030227 psychiatry
Peripheral
Psychiatry and Mental health
Cross-Sectional Studies
Treatment Outcome
nervous system
Neurology
Meta-analysis
biology.protein
Major depressive disorder
Antidepressant
Neurology (clinical)
business
Biomarkers
030217 neurology & neurosurgery
Neurotrophin
Zdroj: European Neuropsychopharmacology. 41:40-51
ISSN: 0924-977X
Popis: The neurotrophin hypothesis indicates that neurotrophic factors are important for the pathophysiology of major depressive disorder (MDD), with alterations in peripheral neurotrophin levels having potential clinical application for MDD. The present meta-analysis aimed to investigate the diagnostic value for MDD of peripheral neurotrophin levels in cross-sectional studies and the association between peripheral neurotrophin levels and the response to antidepressant treatment in longitudinal studies. Published studies in the PubMed and Web of Science databases were systematically searched up to February 2020. The search terms included depressive disorder, neurotrophic factor, serum/plasma and their synonyms. Human studies reporting on BDNF, GDNF, IGF-2, VEGF, NGF, FGF-2, and S100B levels in MDD patients were included. Data comparing MDD patients and healthy controls, and/or between responders and non-responders before and after antidepressant treatment were extracted. A random effects model was used to calculate standardized mean differences. A total of 177 original studies were identified, including 139 cross-sectional and 38 longitudinal studies. Significantly reduced BDNF and NGF levels and significantly elevated IGF-1, VEGF, and S100B levels were reported in MDD patients compared with healthy controls, while GDNF and FGF-2 levels were not significantly different. Furthermore, compared with non-responders, S100B levels at baseline and BDNF levels following treatment were significantly elevated in responders. In addition, there was a significantly elevated level of VEGF after treatment in responders only. In conclusions, alterations in peripheral neurotrophins levels were strongly associated with the biology and the treatment response of MDD. Further investigations are required to examine potential sources of heterogeneity.
Databáze: OpenAIRE
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