Complications of combination intranasal corticosteroids and anti-retroviral therapy
| Autor: | Claire Hopkins, Joel James, J Collins, Lisa Caulley |
|---|---|
| Přispěvatelé: | Epidemiology |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Drug
Pediatrics medicine.medical_specialty business.industry media_common.quotation_subject Avascular necrosis General Medicine medicine.disease Cushing syndrome Otorhinolaryngology SDG 3 - Good Health and Well-being Medicine Nasal administration Ritonavir Airway business Sinusitis media_common Fluticasone medicine.drug |
| Zdroj: | Journal of Laryngology and Otology, 135(12), 1119-1122. Cambridge University Press |
| ISSN: | 1748-5460 0022-2151 |
| Popis: | BackgroundIntranasal corticosteroids are widely used for management of many upper airway diseases because of their ability to effectively deliver local relief of inflammation.Case reportThis paper presents the case of a 51-year-old man with human immunodeficiency virus treated with ritonavir who was started on fluticasone intranasal spray for presumed chronic rhinosinusitis. Months after starting this therapy, he developed symptoms of Cushing's syndrome and avascular necrosis of the shoulder due to the pharmacological interactions between fluticasone and ritonavir.ConclusionAlthough intranasal corticosteroids are deemed a low-risk route of drug administration, clinicians need to be vigilant in appropriately prescribing corticosteroids in the setting of drug potentiators, particularly in these high-risk patients. Alternative corticosteroids such as beclomethasone dipropionate should be considered in such cases. |
| Databáze: | OpenAIRE |
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