Glycaemic fall after a glucose load. A population-based study
| Autor: | Giovanni Boschetti, Anna Bascelli, Laura Schiavon, Federica Guidotti, Alberto Mazza, F. De Lazzari, Valérie Tikhonoff, Edoardo Casiglia, Daniele D'Este, Stefano Masiero, Mario Saugo, Sandro Caffi, S. de Kreutzenberg, Bortolo Martini, Paolo Spinella, Francesco Guglielmi, Ac Pessina |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Blood Glucose Male medicine.medical_specialty Endocrinology Diabetes and Metabolism medicine.medical_treatment Population Medicine (miscellaneous) Physiology Blood Pressure Coronary Disease Age and sex Young Adult Risk Factors Internal medicine Epidemiology medicine Cluster Analysis Humans Insulin Statistical analysis Obesity education Aged Aged 80 and over Metabolic Syndrome Analysis of Variance education.field_of_study Nutrition and Dietetics business.industry Glucose Tolerance Test Middle Aged medicine.disease Population based study Endocrinology Blood pressure Glycemic Index Female Insulin Resistance Metabolic syndrome Cardiology and Cardiovascular Medicine business Follow-Up Studies |
| Zdroj: | Nutrition, Metabolism and Cardiovascular Diseases. 20:727-733 |
| ISSN: | 0939-4753 |
| DOI: | 10.1016/j.numecd.2009.06.012 |
| Popis: | A blood glucose (BG) fall after an oral glucose load has never been described previously at a population level. This study was aimed at looking for a plasma glucose trend after an oral glucose load for possible blood glucose fall if any, and for its impact on coronary mortality at a population level.In subjects from an unselected general population, BG and insulin were detected before and 1 and 2h after a 75-g oral glucose load for insulin sensitivity and β-cell function determination. Blood pressure, blood examinations and left ventricular mass were measured, and mortality was monitored for 18.8±7.7 years. According to discriminant analysis, the population was stratified into cluster 0 (1-h BGfasting BG; n=497) and cluster 1 (1-h BG ≥ fasting BG; n=1733). To avoid any interference of age and sex, statistical analysis was limited to two age-gender-matched cohorts of 490 subjects from each cluster (n=940). Subjects in cluster 0 showed significantly higher insulin sensitivity and β-cell function, lower visceral adiposity and lower blood pressure values. Adjusted coronary mortality was 8 times lower in cluster 0 than 1 (p0.001). The relative risk of belonging to cluster 1 was 5.40 (95% CI 2.22-13.1).It seems that two clusters exist in the general population with respect to their response to an oral glucose load, independent of age and gender. Subjects who respond with a BG decrease could represent a privileged sub-population, where insulin sensitivity and β-cell function are better, some risk factors are less prevalent, and coronary mortality is lower. |
| Databáze: | OpenAIRE |
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