Klebsiella pneumoniae Redistributes Katanin Severing Proteins and Alters Astral Microtubules during Mitosis
| Autor: | Michael Dominic Chua, Alexander Constantine Bogdan, Julian A. Guttman |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Histology Klebsiella pneumoniae Mitosis Katanin Microtubules Cell Line 03 medical and health sciences 0302 clinical medicine Microtubule Humans Lung Ecology Evolution Behavior and Systematics Microtubule severing biology Microtubule cytoskeleton biology.organism_classification 3. Good health Cell biology 030104 developmental biology biology.protein Anatomy Astral microtubules 030217 neurology & neurosurgery Biotechnology |
| Zdroj: | The Anatomical Record. 303:1859-1864 |
| ISSN: | 1932-8494 1932-8486 |
| DOI: | 10.1002/ar.24286 |
| Popis: | Klebsiella pneumoniae has become a growing concern within hospitals due to multidrug resistant strains and increasing mortality rates. Recently, we showed that at the subcellular level, K. pneumoniae compromises the integrity of the epithelia by disassembling the microtubule networks of cells through the actions of katanin microtubule severing proteins. In this study, we report on the observation that mitotic cells are targeted by K. pneumoniae and that during infections, the katanin proteins are excluded from the microtubule organizing centers of dividing cells, resulting in the alteration of the microtubule cytoskeleton. Anat Rec, 2019. © 2019 American Association for Anatomy Anat Rec, 303:1859-1864, 2020. © 2019 American Association for Anatomy. |
| Databáze: | OpenAIRE |
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