Modafinil and orexin system: interactions and medico-legal considerations
| Autor: | Sergio Chieffi, Anna Nunzia Polito, Antonietta Messina, Annarita Lovino, Marcellino Monda, Christian Zammit, Lucia Longhitano, Vincenzo Monda, Francesco Sessa, Domenico Tafuri, Daniela Nicolosi, Ines Villano, Marco Carotenuto, Monica Salerno, Carla Loreto, Giovanni Messina |
|---|---|
| Přispěvatelé: | Salerno, Monica, Villano, Ine, Nicolosi, Daniela, Longhitano, Lucia, Loreto, Carla, Lovino, Annarita, Sessa, Francesco, Polito, Anna Nunzia, Monda, Vincenzo, Chieffi, Sergio, Messina, Antonietta, Monda, Marcellino, Zammit, Christian, Tafuri, Domenico, Messina, Giovanni, Carotenuto, Marco |
| Rok vydání: | 2018 |
| Předmět: |
Genetics and Molecular Biology (all)
0301 basic medicine Medico legal Drug Central Nervous System Sympathetic nervous system Immunology and Microbiology (all) Mental fatigue media_common.quotation_subject medicine.medical_treatment Modafinil Biochemistry 03 medical and health sciences 0302 clinical medicine Cognition medicine Animals Humans Attention Wakefulness media_common Neurons Orexins Biochemistry Genetics and Molecular Biology (all) business.industry Wakefulness-Promoting Agents Orexin Stimulant 030104 developmental biology medicine.anatomical_structure business Neuroscience 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Frontiers in bioscience (Landmark edition). 24(3) |
| ISSN: | 2768-6698 |
| Popis: | Modafinil (Mo) is increasingly being used as an enhancement drug rather than for its therapeutic effects. The effects of this drug have been examined in attention deficit disorders, depression, mental fatigue, and in enhancing concentration. The drug possesses wakefulness-promoting properties which are mediated through the interaction of orexinergic system with the activated sympathetic nervous system. Mo exerts a synergistic effect on the orexin system, controls energy expenditure and strengthens the ability of the individual to exercise. Some view Mo as a drug that enhances sports performance, since it induces a prolonged wakefulness and decreasing the sense of fatigue. These characteristics being similar to conventional stimulants have allowed Mo to emerge as a novel stimulant requiring medico-legal considerations. However, more studies are needed to better understand the mid and long-term effects of the drug on user/abuser. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|