Effects of Full-Length Kisspeptin Administration on Follicular Development in Japanese Black Beef Cows
| Autor: | Hiroko Tsukamura, Fuko Matsuda, Shinya Oishi, Yoshihisa Uenoyama, Kei-ichiro Maeda, Keisuke Nakatsukasa, Satoshi Ohkura, Nobutaka Fujii, Yousuke Naniwa, Shohei Setsuda |
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| Rok vydání: | 2013 |
| Předmět: |
Ovulation
endocrine system medicine.medical_specialty Kisspeptin medicine.drug_class media_common.quotation_subject Biology Oogenesis Japan Ovarian Follicle Ovulation Induction Pituitary Gland Anterior Internal medicine Follicular phase medicine Animals Ovarian follicle Ultrasonography media_common Gonadotropin Estrous cycle Kisspeptins Dose-Response Relationship Drug Fertility Agents Female Luteinizing Hormone Up-Regulation Gonadotropin secretion Kinetics Endocrinology medicine.anatomical_structure Injections Intravenous Original Article Cattle Female Animal Science and Zoology Follicular development Luteinizing hormone hormones hormone substitutes and hormone antagonists Animals Inbred Strains |
| Zdroj: | The Journal of Reproduction and Development ResearcherID |
| ISSN: | 1348-4400 0916-8818 |
| DOI: | 10.1262/jrd.2013-064 |
| Popis: | Kisspeptin is a key molecule that stimulates gonadotropin secretion via release of gonadotropin-releasing hormone (GnRH). In the present study, our aim was to investigate whether kisspeptin has stimulatory effects on follicular development via GnRH/gonadotropin secretion in cows. Japanese Black beef cows were intravenously injected with full-length bovine kisspeptin [Kp-53 (0.2 or 2 nmol/kg)] or vehicle 5 days after they exhibited standing estrus (Day 0). In cows injected with Kp-53 at 2 nmol/kg, the follicular sizes of the first dominant follicles increased on Day 6 and thereafter. Ovulation of the first dominant follicle occurred in 1 out of 4 cows treated with Kp-53 at 2 nmol/kg. Injection of Kp-53 at 2 nmol/kg increased the concentration of plasma luteinizing hormone (LH) but not follicle-stimulating hormone, over a 4-h period following injection in all cows. The present study suggests that administration of full-length kisspeptin causes LH secretion, which is sustained for a few hours, and it is capable of stimulating follicular development and/or ovulation. |
| Databáze: | OpenAIRE |
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