Asymmetric Hydrogenation of Aromatic Heterocyclic Ketones Catalyzed by the MsDPEN–Cp*Ir(III) Complex

Autor:	Masahiko Watanabe, Kunihiko Tsutsumi, Kunihiko Murata, Takeshi Ohkuma, Nobuhito Kurono, Noriyoshi Arai, Noriyuki Utsumi
Jazyk:	angličtina
Rok vydání:	2010
Předmět:	Pharmacology chemistry.chemical_classification Ketone Iridium Catalyst Chemistry Organic Chemistry Asymmetric hydrogenation Chiral Alchohol Enantioselective Reaction Medicinal chemistry Analytical Chemistry Catalysis Asymmetric Hydrogenation Molar ratio
Zdroj:	Heterocycles. 80(1):141-147
ISSN:	0385-5414
Popis:	Asymmetric hydrogenation of aromatic heterocyclic ketones catalyzed by Cp*Ir(OTf)(Msdpen) (MsDPEN = N-(methanesulfonyl)-1,2-diphenylethylenediamine) affords the heterocyclic alcohols in 93% to > 99% ee. The reaction is conducted in a methanolic solution with a substrate-to-catalyst molar ratio of 200-5000 under 15 atm of H2. The heterocyclic rings of substrates are left intact.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81f2ff55fc7360ba58c4cad524da61d2 http://hdl.handle.net/2115/45011 Zobrazit plný text záznamu