A Comparative Study of Tricarbonylmanganese Photoactivatable CO Releasing Molecules (PhotoCORMs) by Using the Myoglobin Assay and Time‐Resolved IR Spectroscopy

Autor:	Johanna Niesel, Rolf Linder, Peter C. Kunz, Wilhelm Huber, Ulrich Schatzschneider, Bernhard Spingler
Přispěvatelé:	University of Zurich, Kunz, Peter C
Rok vydání:	2012
Předmět:	10120 Department of Chemistry Tris Steric effects 1604 Inorganic Chemistry Kinetics Infrared spectroscopy Photochemistry Inorganic Chemistry chemistry.chemical_compound chemistry Myoglobin 540 Chemistry Polymer chemistry Molecule Spectroscopy Stoichiometry
Zdroj:	European Journal of Inorganic Chemistry. 2012:3140-3146
ISSN:	1099-0682 1434-1948
Popis:	Tricarbonylmanganese(I) complexes of the ligands tris(imidazol-4-yl)phosphane (4-tipH), tris(1,4-diisopropylimidazol-2-yl)phosphane (2-tipiPr2), tris(pyridin-2-yl)phosphane (tpp) and tris(N-methylimidazol-2-yl)carbinol (2-ticNMe) were prepared. These act as N,N,N tripodal chelators. The solid-state structure of Mn(CO)3(tpp)]OTf was determined by X-ray diffraction. The potential of these complexes to act as photoactivatable CO-releasing molecules (PhotoCORMs) was studied with the UV/Vis spectroscopy-based myoglobin assay as well as by time-resolved IR spectroscopy. Within the series of compounds prepared, the steric bulk of the imidazolyl groups seems to significantly influence the CO-release kinetics and stoichiometry when using the myoglobin assay. In contrast, the time-resolved IR data suggest release of all carbonyl ligands upon irradiation. This effect points to a much closer association of myoglobin and PhotoCORMs than previously thought and will require further investigation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81ed902eacf882e8b3d4d6c30c7d0916 https://doi.org/10.1002/ejic.201200115 Zobrazit plný text záznamu Plný text ve formátu PDF