Scalable in-hospital decontamination of N95 filtering face-piece respirator with a peracetic acid room disinfection system
| Autor: | Sarah N. Redmond, Shine Raju, Joy A. Buehler, Phillip McClellan, Claudia Hoyen, Sharon K. Miller, Curtis J. Donskey, Melissa Braskie, Jennifer L. Cadnum, Ozan Akkus, Amrita John, Wayne D. Jennings, Daniel F. Li, Kipum Lee |
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| Rok vydání: | 2020 |
| Předmět: |
Microbiology (medical)
Materials science business.product_category Coronavirus disease 2019 (COVID-19) N95 Respirators Epidemiology 010501 environmental sciences 01 natural sciences Geobacillus stearothermophilus 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Material structure Peracetic acid Humans Peracetic Acid 030212 general & internal medicine Respirator Hydrogen peroxide Personal protective equipment Decontamination Aerosolization Levivirus 0105 earth and related environmental sciences Aerosols Cross Infection SARS-CoV-2 Structural integrity COVID-19 Hydrogen Peroxide Human decontamination Pulp and paper industry Infectious Diseases chemistry Environmental science Equipment Contamination Original Article business Disinfectants |
| Zdroj: | Infection Control & Hospital Epidemiology Infection Control and Hospital Epidemiology |
| ISSN: | 1559-6834 0899-823X |
| Popis: | Background:Critical shortages of personal protective equipment, especially N95 respirators, during the coronavirus disease 2019 (COVID-19) pandemic continues to be a source of concern. Novel methods of N95 filtering face-piece respirator decontamination that can be scaled-up for in-hospital use can help address this concern and keep healthcare workers (HCWs) safe.Methods:A multidisciplinary pragmatic study was conducted to evaluate the use of an ultrasonic room high-level disinfection system (HLDS) that generates aerosolized peracetic acid (PAA) and hydrogen peroxide for decontamination of large numbers of N95 respirators. A cycle duration that consistently achieved disinfection of N95 respirators (defined as ≥6 log10 reductions in bacteriophage MS2 and Geobacillus stearothermophilus spores inoculated onto respirators) was identified. The treated masks were assessed for changes to their hydrophobicity, material structure, strap elasticity, and filtration efficiency. PAA and hydrogen peroxide off-gassing from treated masks were also assessed.Results:The PAA room HLDS was effective for disinfection of bacteriophage MS2 and G. stearothermophilus spores on respirators in a 2,447 cubic-foot (69.6 cubic-meter) room with an aerosol deployment time of 16 minutes and a dwell time of 32 minutes. The total cycle time was 1 hour and 16 minutes. After 5 treatment cycles, no adverse effects were detected on filtration efficiency, structural integrity, or strap elasticity. There was no detectable off-gassing of PAA and hydrogen peroxide from the treated masks at 20 and 60 minutes after the disinfection cycle, respectively.Conclusion:The PAA room disinfection system provides a rapidly scalable solution for in-hospital decontamination of large numbers of N95 respirators during the COVID-19 pandemic. |
| Databáze: | OpenAIRE |
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