High Frequency of Severe Telaprevir-associated Skin Eruptions in Clinical Practice
| Autor: | Carlos Gordillo, Javier Sánchez-Pérez, Mar Llamas-Velasco, Raquel Carrascosa, Luisa García-Buey, Tania Marusia Capusan |
|---|---|
| Přispěvatelé: | UAM. Departamento de Medicina |
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male medicine.medical_specialty Medicina Dermatology Antiviral Agents Severity of Illness Index Telaprevir Hospitals University Young Adult 030207 dermatology & venereal diseases 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Pegylated interferon Severity of illness Side-effects Humans Medicine Prospective Studies Young adult Triple therapy Prospective cohort study Aged Skin business.industry Incidence Ribavirin Incidence (epidemiology) General Medicine Hepatitis C Hepatitis C Chronic Middle Aged medicine.disease Telaprevir-related dermatitis chemistry Spain Female Drug Eruptions business Oligopeptides medicine.drug |
| Zdroj: | Biblos-e Archivo. Repositorio Institucional de la UAM instname |
| ISSN: | 0001-5555 |
| DOI: | 10.2340/00015555-2174 |
| Popis: | Since the introduction of telaprevir, administered in combination with pegylated interferon and ribavirin for the treatment of patients with chronic hepatitis C, the incidence and severity of skin eruptions have increased significantly. The aim of this prospective study is to assess the frequency of drug-induced skin eruptions and their clinical and histological characteristics in patients who received the above treatment in daily clinical practice at our hospital. A total of 60 patients were included. The frequency of telaprevir-associated skin eruptions was 48.3%, which is slightly below, but close to, previously described ranges. There was a predominance of an eczematous clinical pattern, and spongiotic dermatitis on histological examination. A slightly high frequency of severe skin eruptions (13.3%) was found in our study series, which may be explained by all our patients being assessed and closely monitored by one or more dermatologists. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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