Pharmacological inhibition of poly(ADP-ribose) polymerase inhibits angiogenesis

Autor: Pal Pacher, Lucas Liaudet, György Haskó, Grzegorz Godlewski, Mohanraj Rajesh, Sandor Batkai, Partha Mukhopadhyay
Rok vydání: 2006
Předmět:
Vascular Endothelial Growth Factor A
Cell Survival
DNA repair
Angiogenesis
Poly ADP ribose polymerase
Biophysics
Angiogenesis Inhibitors
Poly(ADP-ribose) Polymerase Inhibitors
Biology
Biochemistry
Poly (ADP-Ribose) Polymerase Inhibitor
Article
Cell Movement
Humans
Enzyme Inhibitors
Molecular Biology
Cells
Cultured
Polymerase
Cell Proliferation
Tube formation
Cell growth
Angiogenesis Inhibitors/*pharmacology Benzamides/pharmacology Cell Movement/drug effects Cell Proliferation/drug effects Cell Survival/drug effects Cells
Cultured Endothelium
Vascular/cytology/drug effects/growth & development Enzyme Inhibitors/pharmacology Humans Phenanthrenes/pharmacology Poly(ADP-ribose) Polymerases/*antagonists & inhibitors Vascular Endothelial Growth Factor A/antagonists & inhibitors
Cell Biology
Phenanthrenes
Cell biology
Vascular endothelial growth factor A
Benzamides
biology.protein
Cancer research
Endothelium
Vascular
Zdroj: Biochemical and Biophysical Research Communications, vol. 350, no. 2, pp. 352-7
ISSN: 0006-291X
DOI: 10.1016/j.bbrc.2006.09.049
Popis: Poly(ADP-ribose) polymerase (PARP) is a nuclear enzyme which plays an important role in regulating cell death and cellular responses to DNA repair. Pharmacological inhibitors of PARP are being considered as treatment for cancer both in monotherapy as well as in combination with chemotherapeutic agents and radiation, and were also reported to be protective against untoward effects exerted by certain anticancer drugs. Here we show that pharmacological inhibition of PARP with 3-aminobenzamide or PJ-34 dose-dependently reduces VEGF-induced proliferation, migration, and tube formation of human umbilical vein endothelial cells in vitro. These results suggest that treatment with PARP inhibitors may exert additional benefits in various cancers and retinopathies by decreasing angiogenesis.
Databáze: OpenAIRE
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