Prototype micropump for insulin administration based on electrochemical bubble formation
| Autor: | Makoto Haga, Kentaro Okamura, Mariko Kikuchi, Hiroaki Suzuki, Ayumi Kabata, Yasuhiro Kishigami |
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| Rok vydání: | 2008 |
| Předmět: |
Male
medicine.medical_specialty Materials science Working electrode Insulin medicine.medical_treatment Pharmaceutical Science Micropump Diaphragm (mechanical device) Electrolyte Equipment Design Artificial pancreas Dosage form Streptozocin Surgery Diabetes Mellitus Experimental Rats Insulin Infusion Systems medicine Electrochemistry Animals Rats Wistar Biomedical engineering Electrode potential |
| Zdroj: | Journal of pharmaceutical sciences. 97(11) |
| ISSN: | 1520-6017 |
| Popis: | As part of the development of a percutaneous artificial pancreas islet, an insulin injection micropump was fabricated using micromachine techniques. The major components of the device were a thin-film, two-electrode system incorporated in a closed compartment, a silicone rubber diaphragm to separate an electrolyte solution from an insulin solution, a reservoir for insulin and a microneedle attached to the outlet. Hydrogen bubbles were formed on a platinum working electrode when current was applied. This caused the diaphragm to deform and to exert pressure on the insulin solution in the reservoir on the other side of the diaphragm. The injection of insulin was smooth and the injection rate could be controlled by the electrode potential or current. When the insulin solution was injected into streptozotocin-induced diabetic rats, a decrease in plasma glucose level (PGL) was observed which was dependent on the dose of insulin. No substantial difference was observed compared to manual injection. |
| Databáze: | OpenAIRE |
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