Adaptive self-healing electronic epineurium for chronic bidirectional neural interfaces
| Autor: | Jinseok Kim, Ki Jun Yu, Duhwan Seong, Yu Chan Kim, Seunghoe Kim, Inchan Youn, Hyung-Seop Han, Hyojin Lee, Kang Il Song, Hyunseon Seo, Dong Hee Son, Seok Joon Kwon |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Nervous system Central Nervous System Male Computer science Polymers Science Biomedical Engineering Neurosurgery General Physics and Astronomy 02 engineering and technology Signal General Biochemistry Genetics and Molecular Biology Article 03 medical and health sciences Wearable Electronic Devices Epineurium Materials Testing medicine Electronic devices Animals Humans Peripheral Nerves Nerve Tissue lcsh:Science Device failure Brain–computer interface Dynamic stress Multidisciplinary Soft materials fungi food and beverages General Chemistry Prostheses and Implants 021001 nanoscience & nanotechnology Sciatic Nerve Electronics Medical Rats 030104 developmental biology medicine.anatomical_structure Self-healing Models Animal lcsh:Q Gold 0210 nano-technology Biomedical engineering |
| Zdroj: | Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020) Nature Communications |
| ISSN: | 2041-1723 |
| Popis: | Realizing a clinical-grade electronic medicine for peripheral nerve disorders is challenging owing to the lack of rational material design that mimics the dynamic mechanical nature of peripheral nerves. Electronic medicine should be soft and stretchable, to feasibly allow autonomous mechanical nerve adaptation. Herein, we report a new type of neural interface platform, an adaptive self-healing electronic epineurium (A-SEE), which can form compressive stress-free and strain-insensitive electronics-nerve interfaces and enable facile biofluid-resistant self-locking owing to dynamic stress relaxation and water-proof self-bonding properties of intrinsically stretchable and self-healable insulating/conducting materials, respectively. Specifically, the A-SEE does not need to be sutured or glued when implanted, thereby significantly reducing complexity and the operation time of microneurosurgery. In addition, the autonomous mechanical adaptability of the A-SEE to peripheral nerves can significantly reduce the mechanical mismatch at electronics-nerve interfaces, which minimizes nerve compression-induced immune responses and device failure. Though a small amount of Ag leaked from the A-SEE is observed in vivo (17.03 ppm after 32 weeks of implantation), we successfully achieved a bidirectional neural signal recording and stimulation in a rat sciatic nerve model for 14 weeks. In view of our materials strategy and in vivo feasibility, the mechanically adaptive self-healing neural interface would be considered a new implantable platform for a wide range application of electronic medicine for neurological disorders in the human nervous system. Electronic implantable devices should be soft and stretchable, such that nerves can adapt mechanically and autonomously. Here, the authors present an adaptive self-healing electronic epineurium which can form compressive stress-free and strain-insensitive electronics-nerve interfaces. |
| Databáze: | OpenAIRE |
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