Two small regulatory RNAs establish opposing fates of a developmental axis
| Autor: | Fabio Tebaldi Silveira Nogueira, Marja C.P. Timmermans, Daniel H. Chitwood, Shahinez Madi, Michelle T. Juarez |
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| Jazyk: | angličtina |
| Rok vydání: | 2007 |
| Předmět: |
Small interfering RNA
Leucine zipper Trans-acting siRNA Molecular Sequence Data Biology Zea mays Research Communication Gene Expression Regulation Plant microRNA Gene expression Genetics Amino Acid Sequence RNA Small Interfering Transcription factor Body Patterning Plant Proteins Base Sequence Models Genetic Arabidopsis Proteins Cell biology Plant Leaves MicroRNAs RNA Plant Homeobox Sequence Alignment Biogenesis Developmental Biology |
| Popis: | Small RNAs are important regulators of gene expression. In maize, adaxial/abaxial (dorsoventral) leaf polarity is established by an abaxial gradient of microRNA166 (miR166), which spatially restricts the expression domain of class III homeodomain leucine zipper (HD-ZIPIII) transcription factors that specify adaxial/upper fate. Here, we show that leafbladeless1 encodes a key component in the trans-acting small interfering RNA (ta-siRNA) biogenesis pathway that acts on the adaxial side of developing leaves and demarcates the domains of hd-zipIII and miR166 accumulation. Our findings indicate that tasiR-ARF, a ta-siRNA, and miR166 establish opposing domains along the adaxial–abaxial axis, thus revealing a novel mechanism of pattern formation. |
| Databáze: | OpenAIRE |
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