Antibody fucosylation predicts disease severity in secondary dengue infection
| Autor: | Heidi Auerswald, Stylianos Bournazos, Tineke Cantaert, Anavaj Sakuntabhai, Sowath Ly, Philippe Dussart, Jeffrey V. Ravetch, Veasna Duong, Hoa Thi My Vo |
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| Přispěvatelé: | Rockefeller University [New York], Immunologie [Phnom Penh], Institut Pasteur du Cambodge, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Unité de Virologie / Virology Unit [Phnom Penh], Réseau International des Instituts Pasteur (RIIP), Génétique fonctionnelle des maladies infectieuses - Functional Genetics of Infectious Diseases, Centre National de la Recherche Scientifique (CNRS)-Institut Pasteur [Paris], We acknowledge support from the Howard Hughes Medical Institute (HHMI)–Wellcome Trust (208710/Z/17/Z to T.C.), the National Institute of Allergy and Infectious Diseases (NIAID) (R01AI137276 to S.B., U19AI111825 to J.V.R.), and the Rockefeller University. Sample collection from DENV patients was supported by the EU Seventh Framework Programme (FP7/2007-2011). This manuscript was prepared using samples from ZIKV-infected individuals provided by Blood Systems Research Institute (BSRI) from studies funded in whole or in part by NHLBI (HHSN268201100001I), Roche Molecular Systems, Inc., and the Department of Health and Human Services, Biomedical Advanced Research and Development Authority (HHSO100201600010C). The content is solely the responsibility of the authors and does not necessarily represent the official views of BSRI or the NIH., Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Male viruses 030231 tropical medicine Dengue virus medicine.disease_cause Antibodies Viral Solanum Severity of Illness Index Article Dengue fever Pathogenesis Dengue 03 medical and health sciences 0302 clinical medicine Severity of illness Medicine Humans Antibody-dependent enhancement Severe Dengue Child Fucosylation Fucose Multidisciplinary biology business.industry Coinfection Zika Virus Infection Receptors IgG Antibody titer virus diseases Dengue Virus medicine.disease Antibodies Neutralizing Antibody-Dependent Enhancement 3. Good health Immunoglobulin Fc Fragments 030104 developmental biology Immunoglobulin G Immunology biology.protein [SDV.IMM]Life Sciences [q-bio]/Immunology Female Antibody business Sugars |
| Zdroj: | Science Science, American Association for the Advancement of Science, 2021, 372 (6546), pp.1102-1105. ⟨10.1126/science.abc7303⟩ Science, 2021, 372 (6546), pp.1102-1105. ⟨10.1126/science.abc7303⟩ |
| ISSN: | 0036-8075 1095-9203 |
| Popis: | IgG fucosylation predicts dengue severity Secondary infections with dengue virus (DENV) can produce life-threatening symptoms, including thrombocytopenia and hemorrhagic disease, when preexisting DENV-reactive immunoglobulin G1 (IgG1) antibodies promote the infection of immune cells. Although severe dengue symptoms are associated with increased levels of afucosylated IgG1 glycoforms, it is unclear whether this is simply a result of the infection or if it is a preexisting phenomenon that can dictate susceptibility to this disease. Bournazos et al. studied the Fab and Fc structures of anti-DENV antibodies from patients before and after infection and with variable disease outcomes (see the Perspective by de Alwis and Ooi). They found that DENV infection induced specific increases in IgG1 afucosylation, and levels of afucosylated IgG1 could indeed predict dengue disease severity, making IgG1 fucosylation status a potentially useful prognostic tool for the treatment of dengue patients. Science , abc7303, this issue p. 1102 ; see also abj0435, p. 1041 |
| Databáze: | OpenAIRE |
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