Glatiramer acetate reverses cognitive deficits from cranial-irradiated rat by inducing hippocampal neurogenesis
| Autor: | Dao Li Niu, Wei Hua Jia, Qiong Fang Zhou, Jun Tao Zou, Fen He |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Male
medicine.medical_specialty Doublecortin Protein Neurogenesis Immunology Morris water navigation task Hippocampus Nerve Tissue Proteins Hippocampal formation Rats Sprague-Dawley Internal medicine medicine Animals Immunology and Allergy Glatiramer acetate Maze Learning Cognitive deficit Brain-derived neurotrophic factor biology Chemistry Brain-Derived Neurotrophic Factor Calcium-Binding Proteins Microfilament Proteins Dose-Response Relationship Radiation Glatiramer Acetate Rats Disease Models Animal Endocrinology Gene Expression Regulation Neurology biology.protein Cytokines Neurology (clinical) Cranial Irradiation medicine.symptom NeuN Cognition Disorders Peptides Neuroscience Immunosuppressive Agents medicine.drug |
| Zdroj: | Journal of Neuroimmunology. 271:1-7 |
| ISSN: | 0165-5728 |
| DOI: | 10.1016/j.jneuroim.2014.03.015 |
| Popis: | Patients received cranial-irradiation can be affected with cognitive deficits and decreasing hippocampal neurogenesis. In this work, we characterized the cognitive ability and immune-induced neurogenesis of the pre- and post-treated cranial-irradiated rats with Glatiramer acetate (GA), known as a weak CNS auto-antigen. The GA-treated rats displayed better cognitive abilities in Morris water maze (MWM). The numbers of Iba-I-positive microglia, BrdU + /DCX + cells and BrdU + /NeuN + cells in hippocampus increased, which are accompanied with increased IFN-γ and decreased IL-6, IL-4. Furthermore, GA reverted the Th1/Th2 balance. GA treatment can reverse the cognitive deficits caused by cranial irradiation through a mechanism that likely involves immunomodulation. |
| Databáze: | OpenAIRE |
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