The changing face of cancer treatments
| Autor: | Gerald Paul Fitzgerald, David Keohane |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Oncology
medicine.medical_specialty Lung Neoplasms Computed Tomography Angiography medicine.medical_treatment Disease Radiosurgery 03 medical and health sciences Antineoplastic Agents Immunological 0302 clinical medicine Carcinoma Non-Small-Cell Lung Internal medicine Humans Medicine Lung cancer Novel Treatment (New Drug/Intervention Established Drug/Procedure in New Situation) Cisplatin Brain Neoplasms business.industry Cancer General Medicine Immunotherapy Middle Aged medicine.disease Dyspnea Nivolumab Pemetrexed 030220 oncology & carcinogenesis Female business 030217 neurology & neurosurgery medicine.drug Brain metastasis |
| Zdroj: | BMJ Case Rep |
| ISSN: | 1757-790X |
| DOI: | 10.1136/bcr-2018-224784 |
| Popis: | This case demonstrates the effectiveness and ongoing potential of novel lung cancer therapies, specifically immunotherapy agents such as nivolumab, a T-cell programmed death 1 (PD-1) receptor inhibitor. In this case study, our patient had a significant burden of disease with nodal involvement above and below the diaphragm at the time of diagnosis. They were commenced on standard of care therapy: cisplatin and pemetrexed. Despite five cycles of treatment with these agents, their disease progressed significantly with the development of brain metastasis. The patient was switched to a novel immunotherapy agent, nivolumab, and had a complete response to it. Currently, there is no active disease—the lymph nodes have all regressed, the brain metastases have disappeared (with the help of stereotactic surgery) and no further metastases have developed. The patient is tolerating the treatment well and has had no significant adverse reactions to the immunotherapy agent. |
| Databáze: | OpenAIRE |
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