Adjuvant transarterial chemoembolization for patients with hepatocellular carcinoma involving microvascular invasion
| Autor: | Jian-Hong Zhong, Jie Zhang, Bin Chen, Le-Qun Li, Zhi-Yin Liang, Ya-Peng Qi, Bang-De Xiang, Chang-Zhi Chen |
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| Rok vydání: | 2018 |
| Předmět: |
Male
medicine.medical_specialty Prognostic factor Carcinoma Hepatocellular Hepatic resection medicine.medical_treatment Subgroup analysis Antineoplastic Agents Gastroenterology 03 medical and health sciences 0302 clinical medicine Internal medicine Overall survival Medicine Humans In patient Neoplasm Invasiveness Prospective Studies Chemoembolization Therapeutic Prospective cohort study Aged business.industry Liver Neoplasms General Medicine Middle Aged medicine.disease Prognosis Vascular Neoplasms Survival Rate Chemotherapy Adjuvant 030220 oncology & carcinogenesis Hepatocellular carcinoma 030211 gastroenterology & hepatology Surgery Female business Adjuvant |
| Zdroj: | American journal of surgery. 217(4) |
| ISSN: | 1879-1883 |
| Popis: | Background Microvascular invasion (MVI) has recently been reported to be an independent prognostic factor in patients with hepatocellular carcinoma (HCC). This study compared the outcomes of adjuvant transarterial chemoembolization (A-TACE) after hepatic resection (HR) in patients with HCC involving MVI. Methods This prospective study involved 200 consecutive patients with MVI-HCC who underwent HR alone (n = 109) or HR with A-TACE (n = 91).The Kaplan-Meier method was used to compare disease-free survival (DFS) and overall survival (OS). Results The two groups showed similar DFS at 1, 2, and 3 years (P = 0.077). The A-TACE group showed significantly higher OS than the HR-only group (P = 0.030). Subgroup analysis showed that A-TACE was associated with significantly higher DFS and OS among patients with a tumor diameter >5 cm or with multinodular tumors. Conclusions A-TACE may improve postoperative outcomes for MVI-HCC patients, especially those with tumor diameter >5 cm or multinodular tumors. |
| Databáze: | OpenAIRE |
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