Bone mineral density in Turner's syndrome--a longitudinal study
| Autor: | Shahid Husain, Nick Shaw, Tim Marshall, V. K. Rehan, C. S. Smith |
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| Rok vydání: | 1997 |
| Předmět: |
Longitudinal study
medicine.medical_specialty Bone density Bone disease Adolescent Endocrinology Diabetes and Metabolism Osteoporosis Turner Syndrome Endocrinology Bone Density Internal medicine Turner syndrome medicine Humans Longitudinal Studies Risk factor Child Bone mineral business.industry Puberty Estrogens medicine.disease Child Preschool Etiology Female business |
| Zdroj: | Clinical endocrinology. 47(3) |
| ISSN: | 0300-0664 |
| Popis: | OBJECTIVE Osteoporosis is a recognized problem in adult women with Turner's syndrome, the aetiology of which is unclear. The aim of this study was to examine bone mineralization longitudinally in a group of girls with Turner's syndrome and to study the effect of different treatments on bone mineral density. DESIGN A prospective observational study. PATIENTS Eighteen girls with Turner's syndrome aged 4-17 years attending a paediatric endocrine clinic. MEASUREMENTS Bone mineral density of the lumbar spine was assessed using dual energy X-ray absorptiometry at several time points over a 2.5-year period. RESULTS Only one girl had evidence of a significant reduction in bone density when comparisons were made with control data related to body weight and pubertal status. No advantage was found for any form of treatment in optimizing bone mineralization. CONCLUSIONS As there is little evidence of reduced bone mineral density in girls with Turner's syndrome there is no justification for an early introduction of oestrogen replacement during the prepubertal years. |
| Databáze: | OpenAIRE |
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