The Impact of Social Factors on Human Immunodeficiency Virus and Hepatitis C Virus Co-Infection in a Minority Region of Si-Chuan, the People's Republic of China: A Population-Based Survey and Testing Study

Autor: Caiting Dong, Wenhong Lai, Li Liu, Song Zhibin, Daying Wei, Lei Nan, Yihui Yang, Z. Jennifer Huang, Huang Jun, Honglu Liu, Ying Hu, Qixing Wang, Frank Y. Wong, Zhang Jianxun, Maria C. Martin, Deng Hongxia, Bin Deng, Wen Yang, Guangming Qin, Linglin Zhang
Rok vydání: 2014
Předmět:
Male
Viral Diseases
Epidemiology
Gastroenterology and hepatology
Hepacivirus
lcsh:Medicine
HIV Infections
medicine.disease_cause
Hepatitis
Drug Users
Immunodeficiency Viruses
Drug control
Risk Factors
Young adult
lcsh:Science
Multidisciplinary
biology
Coinfection
virus diseases
Hepatitis C
Middle Aged
Substance abuse
Infectious hepatitis
Sexual Partners
Infectious Diseases
Medical Microbiology
Viral Pathogens
Female
Research Article
Adult
China
Adolescent
Hepatitis C virus
Sexually Transmitted Diseases
Microbiology
Infectious Disease Epidemiology
Young Adult
Sex Factors
medicine
Humans
Microbial Pathogens
Liver diseases
Medicine and health sciences
business.industry
lcsh:R
HIV
Biology and Life Sciences
Odds ratio
medicine.disease
biology.organism_classification
Social Epidemiology
Socioeconomic Factors
Immunology
lcsh:Q
business
Demography
Zdroj: PLoS ONE
PLoS ONE, Vol 9, Iss 7, p e101241 (2014)
ISSN: 1932-6203
Popis: BACKGROUND: While many human immunodeficiency virus (HIV) studies have been performed in Liangshan, most were focused only on HIV infection and based on a sampling survey. In order to fully understand HIV and hepatitis C virus (HCV) prevalence and related risk factors in this region, this study implemented in 2009, included a survey, physical examination, HIV and HCV test in two towns. METHODS: All residents in two towns of the Butuo county were provided a physical examination and blood tests for HIV and HCV, and then followed by an interview for questionnaire. RESULTS: In total, 10,104 residents (92.4%) were enrolled and 9,179 blood samples were collected for HIV and HCV testing, 6,072 were from individuals >14 years old. The rates of HIV, HCV, and HIV/HCV co-infection were 11.4%, 14.0%, and 7.7%, respectively for >14-year-old residents. The 25-34 yr age group had the highest prevalence of HIV, HCV, and HIV/HCV co-infections, reaching 24.4%, 26.2% and 16.0%, respectively. Overall, males had a much higher prevalence of all infections than females (HIV: 16.3% vs. 6.8%, HCV: 24.6% vs. 3.9%, HIV/HCV co-infected: 14.7% vs. 1.1%, respectively; P = 0.000). Approximately half of intravenous drug users tested positive for HIV (48.7%) and 68.4% tested positive for HCV. Logistic regression analysis showed that five factors were significantly associated with HIV and HCV infection: gender (odds ratio [OR] = 5.8), education (OR = 2.29); occupation (student as reference; farmer: OR = 5.02, migrant worker: OR = 6.12); drug abuse (OR = 18.0); and multiple sexual partners (OR = 2.92). Knowledge of HIV was not associated with infection. CONCLUSION: HIV and HCV prevalence in the Liangshan region is very serious and drug use, multiple sexual partners, and low education levels were the three main risk factors. The government should focus on improving education and personal health awareness while enhancing drug control programs.
Databáze: OpenAIRE
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