Effect of Pregabalin and Dexamethasone on Postoperative Analgesia after Septoplasty
| Autor: | Hakan Bayir, Akcan Akkaya, Tayfun Apuhan, Abdullah Demirhan, Hasan Kocoglu, Veysel Yurttaş, Murat Bilgi, Isa Yildiz, Umit Yasar Tekelioglu, Uzeyir Gok |
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| Přispěvatelé: | BAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Demirhan, Abdullah, Akkaya, Akcan, Tekelioğlu, Ümit Yaşar, Apuhan, Tayfun, Bilgi, Murat, Yurttaş, Veysel, Bayır, Hakan, Yıldız, İsa, Gök, Üzeyir, Koçoğlu, Hasan |
| Rok vydání: | 2014 |
| Předmět: |
medicine.medical_specialty
Article Subject medicine.medical_treatment Pregabalin Placebo Dexamethasone Ondansetron Pain assessment medicine Postoperative lcsh:R5-920 Septoplasty business.industry Surgery Pethidine Anesthesiology and Pain Medicine Anesthesia Clinical Study Neurology (clinical) Tramadol lcsh:Medicine (General) business medicine.drug |
| Zdroj: | Pain Research and Treatment Pain Research and Treatment, Vol 2014 (2014) |
| ISSN: | 2090-1550 2090-1542 |
| DOI: | 10.1155/2014/850794 |
| Popis: | Objectives. The aim of this study was to explore effect of a combination of pregabalin and dexamethasone on pain control after septoplasty operations. Methods. In this study, 90 patients who were scheduled for septoplasty under general anesthesia were randomly assigned into groups that received either placebo (Group C), pregabalin (Group P), or pregabalin and dexamethasone (Group PD). Preoperatively, patients received either pregabalin 300 mg one hour before surgery, dexamethasone 8 mg intravenously during induction, or placebo according to their allocation. Postoperative pain treatment included tramadol and diclofenac sodium 30 minutes before the end of the operation. Numeric rating scale (NRS) for pain assessment, side effects, and consumption of tramadol, pethidine, and ondansetron were recorded. Results. The median NRS score at the postoperative 0 and the 2nd h was significantly higher in Group C than in Group P and Group PD ( for both). The 24 h tramadol and pethidine, consumptions were significantly reduced in Groups P and PD compared to Group C (). The incidence of blurred vision was significantly higher in Group PD compared to Group C within both 0–2 h and 0–24 h periods (, resp.). Conclusions. We conclude that administration of 300 mg pregabalin preoperatively may be an adequate choice for pain control after septoplasty. Addition of dexamethasone does not significantly reduce pain in these patients. |
| Databáze: | OpenAIRE |
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