Infections Occurring During the Courses of Anticancer Chemotherapy in Children with All: A Retrospective Analysis of 59 Patients
| Autor: | Mikko Perkkiö, Jaana Rahiala, Pekka Riikonen |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Male
medicine.medical_specialty Neutropenia Adolescent Antineoplastic Agents Bacteremia Fever of Unknown Origin Recurrence Internal medicine Humans Medicine Fever of unknown origin Child Respiratory Tract Infections Retrospective Studies Leukopenia Respiratory tract infections business.industry Infant Retrospective cohort study Bacterial Infections Hematology Precursor Cell Lymphoblastic Leukemia-Lymphoma medicine.disease Focal infection theory Focal Infection Surgery Hospitalization Oncology Virus Diseases Child Preschool Pediatrics Perinatology and Child Health Female medicine.symptom business Febrile neutropenia |
| Zdroj: | Pediatric Hematology and Oncology. 15:165-174 |
| ISSN: | 1521-0669 0888-0018 |
| DOI: | 10.3109/08880019809167231 |
| Popis: | In a retrospective analysis we evaluated the occurrence of infections in 59 children with acute lymphoblastic leukemia (ALL) during the entire duration of their anticancer chemotherapy. We recorded a total of 245 infection episodes, 118 (50%) being during neutropenia and 119 (50%) during nonneutropenia. The infections most commonly detected during neutropenia were fevers of undetermined origin (36%), clinically or microbiologically defined focal infections (33%), and bacteremias (28%). During nonneutropenia, upper respiratory tract infections (55%) were the most common. Patients needed hospitalization for infections for a total of 1951 days (i.e., a mean of 33 days per patient) and the mean number of infection episodes was 4.2 per patient. Recurrent fever developed in 21% of the children with bacteremia. Mortality caused by bacteremias was 10%. Infections during the chemotherapy of ALL were a significant cause of morbidity in children, but mortality was low. |
| Databáze: | OpenAIRE |
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