Significance of chromosomal abnormalities in a malignant giant cell tumor of bone

Autor:	Julia A. Bridge, James R. Neff, Paramjit Bhatia, Barbara J. Mouron
Rok vydání:	1991
Předmět:	Chromosome Aberrations Malignant Giant Cell Tumor Sacrum Cancer Research medicine.medical_specialty Pathology Giant Cell Tumors Cytogenetics Bone Neoplasms Chromosome Disorders Karyotype Anatomy Middle Aged Biology Karyotyping Genetics medicine Humans Female Molecular Biology Metaphase
Zdroj:	Cancer Genetics and Cytogenetics. 57:87-92
ISSN:	0165-4608
DOI:	10.1016/0165-4608(91)90193-x
Popis:	Cytogenetic analysis of a malignant giant cell tumor of the sacrum from a 62-year-old female revealed the following chromosomal complement: 47,XX, -1, -11, +22,del(2)(p22),t(7;7) (p22;q32), +der(1)t(1;11;21)(p32;q13;q22), +der(19)t(19;?)(q13.4;?), der(8)t(8;?)(p11;?), der(7)t(17;?)(p13;?). Metaphase cells with 92-127 chromosomes sharing identical structural abnormalities detected in the near-diploid cells were also observed. Several of these abnormalities have previously been described in the benign giant cell tumors supporting a direct relationship between these benign and malignant neoplastic counterparts.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81d7c2f9747bf8a5f6c2d3cd363a5fd5 https://doi.org/10.1016/0165-4608(91)90193-x Zobrazit plný text záznamu