Morin attenuates neurobehavioural deficits, hippocampal oxidative stress, inflammation, and apoptosis in rats co-exposed to bisphenol S and diethyl phthalate

Autor: Emmanuel Ifeanyichukwu Ugwor, Oluwatosin Adebisi Dosumu, Ofem Effiom Eteng, Ceaser Antiya Moses, Chukwuka Uzoamaka Ogbonna, Adewale Segun James, Abdulwasiu Oladokun Adeleye, Mohammed Emmanuel Ilavbarhe, Florence Ajasa, Oluwakemi Olawuyi, Regina Ngozi Ugbaja
Rok vydání: 2022
Předmět:
Zdroj: Brain Research. 1794:148068
ISSN: 0006-8993
DOI: 10.1016/j.brainres.2022.148068
Popis: Endocrine-disrupting pollutants (EDPs) remain pervasive in the environment. Bisphenol S (BPS) and diethyl phthalates (DEP) are commonly used to replace the more toxic EDPs. However, it is unclear if they induce neurotoxicity, like their predecessors. Morin possesses relevant neuro-pharmacological activities. Hence, we sought to evaluate the protective effects of morin against the neurotoxic effects previously reported for EDPs. Male Wistar rats were exposed to a mixture of BPS and DEP (MBD) and treated with morin for 21 days. Behavioural assessments were conducted, and the hippocampal tissues were processed for analysis. Rats exposed to MBD presented anxiety-like behaviours, impaired cognitive and motor functions compared to the control group. MBD exposure induced hyperactivity of neurosignalling enzymes (AChE, ADA, MAO-A) and depleted hippocampal antioxidants (SOD, CAT, GPx, and GSH). MBD exposure increased calcium levels and inhibited total Ca
Databáze: OpenAIRE
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