Association of apolipoprotein A5 gene variants with metabolic syndrome in Tunisian population

Autor: Mariem Chargui, Meriem Hechmi, Zinet Turki, Christophe Normand, Majdi Nagara, Abdelhamid Baraket, Haifa Jmel, Ines Kamoun, Ramon Gomis, Rym Kefi, Henda Jamoussi, Sonia Abdelhak, Florin Grigorescu, Abdelmajid Abid, Safa Romdhane, Sihem Ben Fadhel, Sahar Elouej, Sonia Bahri, Hamza Dallali, Yossra Ben Halima, Afaf Bahlous
Přispěvatelé: Laboratoire de Génomique Biomédicale et Oncogénétique - Biomedical Genomics and Oncogenetics Laboratory (LR11IPT05), Université de Tunis El Manar (UTM)-Institut Pasteur de Tunis, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Université de Tunis El Manar (UTM), Université de Carthage - University of Carthage, Génétique Médicale et Génomique Fonctionnelle (GMGF), Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital de la Timone [CHU - APHM] (TIMONE)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut National de Nutrition et de Technologie Alimentaire (Tunis) (INNTA), Laboratoire central de biologie médicale, Institut Pasteur de Tunis, Institut Pasteur de Tunis, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Universitat de Barcelona (UB), Institut Pasteur du Maroc, Réseau International des Instituts Pasteur (RIIP), Nutrition et Alimentation des Populations aux Suds (NutriPass), Université Montpellier 1 (UM1)-Institut de Recherche pour le Développement (IRD)-Université Montpellier 2 - Sciences et Techniques (UM2)-Université de Montpellier (UM)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), This work was supported by the E.C. Grant agreement no. 279171-1 for FP7 project MEDIGENE and by the Tunisian Ministry of Public Health and the Tunisian Ministry of Higher Education and Scientific Research (LR11IPT05)., Institut National de la Santé et de la Recherche Médicale (INSERM)-Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital de la Timone [CHU - APHM] (TIMONE)-Centre National de la Recherche Scientifique (CNRS), Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), Institut de Recherche pour le Développement (IRD)-Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Université de Montpellier (UM)
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Male
0301 basic medicine
Endocrinology
Diabetes and Metabolism
Metabolic disorders
MESH: Tunisia/epidemiology
MESH: Metabolic Syndrome/epidemiology
MESH: Genotype
Endocrinology
Gene Frequency
Polymorphism (computer science)
MESH: Triglycerides/blood
Genotype
Maladie métabolique
Afrique du Nord
MESH: Genetic Association Studies
Metabolic Syndrome
Genetics
MESH: Aged
education.field_of_study
MESH: Middle Aged
MESH: Genetic Predisposition to Disease
Association génétique
General Medicine
Middle Aged
MESH: Metabolic Syndrome/blood
MESH: Case-Control Studies
3. Good health
APOA5 gene
Phenotype
Cohort
Female
Adult
Tunisia
Population
Polymorphisme
Quantitative trait locus
Biology
APOA5
MESH: Phenotype
Polymorphism
Single Nucleotide
03 medical and health sciences
medicine
MESH: Gene Frequency
Humans
SNP
Genetic Predisposition to Disease
Polymorphism
education
Genetic Association Studies
Triglycerides
Aged
Genetic association
MESH: Lipid Metabolism/genetics
MESH: Humans
MESH: Polymorphism
Single Nucleotide
MESH: Adult
Lipid Metabolism
medicine.disease
North Africa
MESH: Male
030104 developmental biology
Apolipoprotein A-V
Case-Control Studies
Metabolic syndrome
MESH: Metabolic Syndrome/genetics
MESH: Apolipoprotein A-V/genetics
MESH: Female
[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Zdroj: Annales d'Endocrinologie
Annales d'Endocrinologie, 2017, 78 (3), pp.146--155. ⟨10.1016/j.ando.2017.01.005⟩
Annales d'Endocrinologie, Elsevier Masson, 2017, 78 (3), pp.146--155. ⟨10.1016/j.ando.2017.01.005⟩
ISSN: 0003-4266
2213-3941
DOI: 10.1016/j.ando.2017.01.005⟩
Popis: Aim of the study APOA5 has been linked to metabolic syndrome (MetS) or its traits in several populations. In North Africa, only the Moroccan population was investigated. Our aim is to assess the association between APOA5 gene polymorphisms with the susceptibility to MetS and its components in the Tunisian population. Materials and methods A total of 594 participants from the Tunisian population were genotyped for two polymorphisms rs3135506 and rs651821 located in APOA5 gene using KASPar technology. Statistical analyses were performed using R software. Results The SNP rs651821 increased the risk of MetS under the dominant model (OR = 1.91 [1.17–3.12], P = 0.008) whereas the variant rs3135506 was not associated with MetS. After stratification of the cohort following the sex, only the variant rs651821 showed a significant association with MetS among the women group. The influence of the geographic origin of the studied population on the genotype distribution of APOA5 variants showed that the variant rs651821 was significantly associated with MetS only for the Northern population. The association analyses of the variants rs651821 and rs3135506 with different quantitative traits of MetS showed a significant association only between the variant rs3135506 and triglycerides levels. Conclusion This is the first study reporting the association of APOA5 gene variants with MetS in Tunisia. Our study emphasizes the role of APOA5 variants in the regulation of the triglycerides blood levels. Further studies are needed to confirm the clinical relevance of these associations and to better understand the physiopathology of the MetS.
Databáze: OpenAIRE
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