Patients with idiopathic rapid-eye-movement sleep behavior disorder show normal gastric motility assessed by the 13C-octanoate breath test
| Autor: | Jens Carsten Möller, Katharina Bohne, Wolfgang H. Oertel, Katrin Schmittinger, Johannes J. Tebbe, Geert Mayer, Maren Bodden, Karla Eggert, Karin Stiasny-Kolster, Katharina Mankel, Maria Stamelou, Marcus M. Unger |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Male medicine.medical_specialty Parkinson's disease Gastrointestinal Diseases Gastric motility Rapid eye movement sleep REM Sleep Behavior Disorder Disease Sensitivity and Specificity Gastroenterology REM sleep behavior disorder Enteric Nervous System Behavior disorder Internal medicine medicine Humans Aged Breath test Carbon Isotopes medicine.diagnostic_test Gastric emptying business.industry digestive oral and skin physiology Parkinson Disease Middle Aged medicine.disease Endocrinology Breath Tests Gastric Emptying Neurology Female Neurology (clinical) Caprylates business |
| Zdroj: | Movement Disorders. 26:2559-2563 |
| ISSN: | 0885-3185 |
| DOI: | 10.1002/mds.23933 |
| Popis: | Background: Delayed gastric emptying is a non-motor symptom of Parkinson's disease. Few data exist on gastric emptying in early-stage Parkinson's disease. In idiopathic rapid-eye-movement sleep behavior disorder, a presumable pre-motor stage of Parkinson's disease, gastric emptying has not yet been investigated. Methods: Twenty healthy controls, 13 patients with idiopathic rapid-eye-movement sleep behavior disorder, and 39 patients with Parkinson's disease patients underwent standardized testing for gastric emptying with the 13C-octanoate breath test. Results: Gastric emptying was significantly delayed in drug-naive (P < .001) and in treated Parkinson's disease patients (P < .001), but normal in patients with idiopathic rapid-eye-movement sleep behavior disorder. Conclusions: Our study confirms delayed gastric emptying in drug-naive, early-stage Parkinson's disease. Normal gastric emptying in idiopathic rapid-eye-movement sleep behavior disorder might be explained by the fact that neurodegenerative changes in structures modulating gastric motility are not severe enough to cause a functional deficit that can be detected by the 13C-octanoate breath test. © 2011 Movement Disorder Society |
| Databáze: | OpenAIRE |
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