Early maternal separation enhances melanoma progression in adult female mice by immune mechanisms
| Autor: | Wesley Lyeverton Correia Ribeiro, Francisco Stefânio Barreto, Manoel Odorico de Moraes Filho, Caren Nádia Soares de Sousa, Danielle Silveira Macêdo, Bruno C. Cavalcanti, Germana Silva Vasconcelos, Paulo Goberlânio de Barros Silva, Ana Paula Negreiros Nunes |
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| Rok vydání: | 2021 |
| Předmět: |
DNA damage
Neuroimmunomodulation Melanoma Experimental Apoptosis General Biochemistry Genetics and Molecular Biology 03 medical and health sciences Leukocyte Count Mice 0302 clinical medicine Sex Factors History and Philosophy of Science Stress Physiological Medicine Animals Interleukin 6 Melanoma PI3K/AKT/mTOR pathway Cell Proliferation biology Behavior Animal business.industry Cell growth General Neuroscience Maternal Deprivation Immunity Cancer medicine.disease Disease Models Animal Tumor progression 030220 oncology & carcinogenesis Cancer research biology.protein Disease Progression Female Disease Susceptibility Health Impact Assessment business 030217 neurology & neurosurgery Biomarkers DNA Damage |
| Zdroj: | Annals of the New York Academy of SciencesReferences. 1502(1) |
| ISSN: | 1749-6632 |
| Popis: | Maternal separation (MS) is a risk factor for major depressive disorder. Both cancer and depression seem to share a common biological link. Here, we evaluated the progression of melanoma and the underlying mechanisms related to this progression, namely cell proliferation and apoptosis, in adult female mice exposed to MS. Female C57BL/6 mice were exposed to MS for 60 min/day during the first 2 postnatal weeks (here called MS mice) or left undisturbed (here called non-MS mice). Melanoma cells were inoculated subcutaneously into the axillary region of adult animals, and tumor progression was evaluated for 25 days. Adult MS mice presented depressive-like behavior and working memory deficits. MS accelerated murine melanoma growth by mechanisms related to decreased apoptosis and increased cell proliferation rate, such as increased expression of IL-6 and mTOR. MS stimulated eukaryotic elongation factor 2 expression and increased the number of circulating monocytes and DNA damage in peripheral blood leukocytes, an effect associated with oxidative DNA damage. In conclusion, MS accelerated the progression of murine melanoma by mechanisms related to tumor proliferation and apoptosis, revealing a relationship between adverse childhood experiences and cancer progression, particularly melanoma. |
| Databáze: | OpenAIRE |
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