Nanoparticle-Based Delivery of Tumor Suppressor microRNA for Cancer Therapy
| Autor: | Roisin M. Dwyer, Clodagh P O'Neill |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Dendrimers
Cancer therapy Antineoplastic Agents Review Therapeutic targeting nanoparticle delivery law.invention Extracellular Vesicles Mice law In vivo Neoplasms microRNA Polyamines medicine Animals Humans tumor suppressor mirna Molecular Targeted Therapy lcsh:QH301-705.5 business.industry Cancer General Medicine medicine.disease Xenograft Model Antitumor Assays Gene Expression Regulation Neoplastic MicroRNAs lcsh:Biology (General) Liposomes Cancer research Nanoparticles cancer therapy Suppressor business Function (biology) |
| Zdroj: | Cells, Vol 9, Iss 2, p 521 (2020) Cells |
| ISSN: | 2073-4409 |
| Popis: | Improved understanding of microRNA expression and function in cancer has revealed a range of microRNAs that negatively regulate many oncogenic pathways, thus representing potent tumor suppressors. Therapeutic targeting of the expression of these microRNAs to the site of tumors and metastases provides a promising avenue for cancer therapy. To overcome challenges associated with microRNA degradation, transient expression and poor targeting, novel nanoparticles are being developed and employed to shield microRNAs for tumor-targeted delivery. This review focuses on studies describing a variety of both natural and synthetic nanoparticle delivery vehicles that have been engineered for tumor-targeted delivery of tumor suppressor microRNAs in vivo. |
| Databáze: | OpenAIRE |
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