Chemical constituents from the bark of the Cameroonian mahogany Trichilia emetica Vahl (Meliaceae)
| Autor: | Anatole Guy Blaise Azebaze, Hans-Georg Stammler, Marcel Frese, Gervais Mouthé Happi, Alexis Sylvain W. Mbobda, Beate Neumann, Willifred Dongmo T. Tsopgni, Simeon F. Kouam, Norbert Sewald, Bruno Ndjakou Lenta |
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| Rok vydání: | 2019 |
| Předmět: |
Lignoceric acid
Plant Science Limonoid 01 natural sciences Biochemistry Protocatechuic acid chemistry.chemical_compound medicine Meliaceae Steroid Stigmasterol biology Traditional medicine 010405 organic chemistry biology.organism_classification 0104 chemical sciences 010404 medicinal & biomolecular chemistry chemistry Phytochemical Trichilia emetica visual_art visual_art.visual_art_medium Bark X-ray structure Agronomy and Crop Science Biotechnology medicine.drug |
| Zdroj: | Phytochemistry Letters. 33:49-54 |
| ISSN: | 1874-3900 |
| DOI: | 10.1016/j.phytol.2019.07.009 |
| Popis: | Phytochemical investigation of the stem bark extract of Trichilia emetica led to the isolation of two new naturally occurring compounds including a prieurianin-class limonoid named trichirokin (1) and the steroid ergosta-5,24(28)-diene-3S, 16S, 20S-triol (4), along with nine known compounds characterized as rohituka-3 (3), rohituka-9 (2), scopoletin, benzoic acid, protocatechuic acid, lignoceric acid, beta-sitosterol, stigmasterol and beta-sitosterol-3-O-beta-D-glucopyranoside. The crystal structures of rohituka-3 (3) and ergosta-5,24(28)-diene-3S, 16S, 20S-triol (4) are reported here for the first time. The structures of the compounds were elucidated by extensive spectroscopic and spectrometric data interpretation. The stereochemistry of compound 1 was established on the basis of its NOESY spectrum and the comparison of its optical rotation value with that of its congener 2. None of the reported compounds displayed antibacterial or cytotoxic activity. |
| Databáze: | OpenAIRE |
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