Response surface optimization of phenolic compounds from jabuticaba (Myrciaria cauliflora [Mart.] O.Berg) seeds: Antioxidant, antimicrobial, antihyperglycemic, antihypertensive and cytotoxic assessments
| Autor: | Mingchun Wen, Mariana Araújo Vieira do Carmo, Anderson S. Sant'Ana, Daniel Granato, Mariza Boscacci Marques, Fereidoon Shahidi, Neiva Deliberali Rosso, Maria Inés Genovese, Marianna M. Furtado, Takao Myoda, Luciana Azevedo, Won Young Oh, Thiago Mendanha Cruz, Marina Fidelis, Liang Zhang, Nora Pap |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Antioxidant
Myrtaceae medicine.medical_treatment Angiotensin-Converting Enzyme Inhibitors Microbial Sensitivity Tests Toxicology Antioxidants 03 medical and health sciences Ingredient chemistry.chemical_compound 0404 agricultural biotechnology Anti-Infective Agents Phenols Cell Line Tumor medicine Humans Hypoglycemic Agents Bioassay Food science Cytotoxicity Antihypertensive Agents 030304 developmental biology 0303 health sciences Plant Extracts Chemistry Extraction (chemistry) ANTIOXIDANTES 04 agricultural and veterinary sciences General Medicine Antimicrobial Antineoplastic Agents Phytogenic 040401 food science Seeds Lipid Peroxidation Food Science Castalagin Ellagic acid |
| Zdroj: | Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
| ISSN: | 0278-6915 |
| DOI: | 10.1016/j.fct.2020.111439 |
| Popis: | The aim of this study was to evaluate the effects of different solvents and maximize the extraction of bioactive compounds from jabuticaba (Myrciaria cauliflora) seeds. In general, the solvent system composed of water and propanone (52:48 v/v) modified the extract polarity and increased extraction yield of bioactive compounds. The optimized extract presented antioxidant capacity measured by different chemical and biological assays. The optimized extract exerted antiproliferative and cytotoxic effects against A549 and HCT8 cells, antimicrobial and antihemolytic effects, inhibited α-amylase/α-glucosidase activities and presented in vitro antihypertensive effect. Nonetheless, the optimized extract showed no cytotoxicity in a human cell model (IMR90). Vescalagin, castalagin and ellagic acid were the major phenolic compounds in the optimized extract. Our results show that jabuticaba seed may be a potential ingredient for the development of potentially functional foods. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect