Leydig and Sertoli Cell Function in Normal and Oligospermic Males: A Preliminary Report
| Autor: | John W. Lloyd, John F. Stecker |
|---|---|
| Rok vydání: | 1978 |
| Předmět: |
Adult
Male endocrine system medicine.medical_specialty Follicle-stimulating hormone Internal medicine Testis Cyclic AMP medicine Humans Sertoli Cells Leydig cell urogenital system Chemistry Leydig Cells Obstetrics and Gynecology Oligospermia Luteinizing Hormone medicine.disease Sertoli cell Adenosine medicine.anatomical_structure Endocrinology Reproductive Medicine Follicle Stimulating Hormone Luteinizing hormone Spermatogenesis hormones hormone substitutes and hormone antagonists medicine.drug Hormone |
| Zdroj: | Fertility and Sterility. 29:204-207 |
| ISSN: | 0015-0282 |
| DOI: | 10.1016/s0015-0282(16)43100-6 |
| Popis: | Sertoli and Leydig cell function was evaluated in patients with oligospermia. Testicular biopsy specimens were incubated in vitro with follicle-stimulating hormone (FSH) or luteinizing hormone (LH), and the amount of cyclic adenosine 3′:5′-monophosphate (cyclic AMP) generated was measured. Cyclic AMP has been shown to be the intracellular mediator for the pituitary gonadotropins FSH and LH. The amount generated by the Sertoli cells in response to FSH, and by the Leydig cells in response to LH, was contrasted with that in age-matched, normal control subjects. The Leydig cell response was similar in both groups. However, the amount of cyclic AMP generated by the Sertoli cells from oligospermie males was much less when compared with normal control subjects. This finding suggests a possible metabolic abnormality in the Sertoli cells of patients with oligospermia which might, in turn, alter spermatogenesis. |
| Databáze: | OpenAIRE |
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