Varicella Zoster Virus Necrotizing Retinitis in Two Patients with Idiopathic CD4 Lymphocytopenia

Autor: Ivana K. Kim, Maria Stephanie R Jardeleza, Leo A. Kim, Meenakashi Gupta, Ann Marie Lobo, Marlene L. Durand
Rok vydání: 2015
Předmět:
Adult
CD4-Positive T-Lymphocytes
Male
Herpesvirus 3
Human
medicine.medical_specialty
Pathology
viruses
medicine.medical_treatment
Human immunodeficiency virus (HIV)
Acyclovir
Progressive outer retinal necrosis
Retinitis
medicine.disease_cause
Antiviral Agents
Polymerase Chain Reaction
03 medical and health sciences
0302 clinical medicine
Blurred vision
HIV Seronegativity
Lymphopenia
Vitrectomy
Viral retinitis
Humans
Immunology and Allergy
Medicine
Fluorescein Angiography
integumentary system
business.industry
Varicella zoster virus
virus diseases
Retinal Necrosis Syndrome
Acute
Valine
Immunosuppression
Middle Aged
medicine.disease
Dermatology
eye diseases
CD4 Lymphocyte Count
medicine.infectious_disease
Ophthalmology
Valacyclovir
Herpes Zoster Ophthalmicus
030221 ophthalmology & optometry
Lymphocytopenia
medicine.symptom
business
Tomography
Optical Coherence
030217 neurology & neurosurgery
Zdroj: Ocular Immunology and Inflammation. 24:544-548
ISSN: 1744-5078
0927-3948
DOI: 10.3109/09273948.2015.1034376
Popis: Progressive outer retinal necrosis (PORN) associated with varicella zoster virus (VZV) is usually diagnosed in HIV positive or immunosuppressed patients. We report two cases of immunocompetent patients with necrotizing viral retinitis found to have idiopathic CD4 lymphocytopenia.Clinical presentation, examination, imaging, and laboratory testing of two patients with VZV retinitis are presented.An HIV negative patient with history of herpes zoster presented with rapid loss of vision and examination consistent with PORN. PCR testing confirmed VZV. Lymphocytopenia was noted with a CD4 count of 25/mm(3). A second HIV negative patient presented with blurred vision and lid swelling and was found to have peripheral VZV retinitis confirmed by PCR. Laboratory workup revealed lymphocytopenia with a CD4 count of 133/mm(3).VZV necrotizing retinitis classic for PORN can occur in HIV negative patients. Idiopathic CD4 lymphocytopenia should be considered healthy patients who develop ocular infections seen in the immunocompromised.
Databáze: OpenAIRE
Externí odkaz: