Vitamin D Status, Disease Activity, and Endothelial Dysfunction in Early Rheumatoid Arthritis Patients
| Autor: | Alexandru Caraba, Marius Murariu, Ioana Mozos, I. Romosan, Viorica Crisan |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Male
medicine.medical_specialty Endothelium Article Subject Clinical Biochemistry Arthritis Inflammation Vasodilation 030204 cardiovascular system & hematology Arthritis Rheumatoid 03 medical and health sciences 0302 clinical medicine Insulin resistance Internal medicine Genetics medicine Vitamin D and neurology Humans Endothelial dysfunction Vitamin D Molecular Biology Aged 030203 arthritis & rheumatology lcsh:R5-920 business.industry Biochemistry (medical) General Medicine Middle Aged medicine.disease medicine.anatomical_structure Endocrinology Cardiovascular Diseases Rheumatoid arthritis Female Endothelium Vascular medicine.symptom Insulin Resistance business lcsh:Medicine (General) Biomarkers Research Article |
| Zdroj: | Disease Markers, Vol 2017 (2017) Disease Markers |
| ISSN: | 0278-0240 |
| DOI: | 10.1155/2017/5241012 |
| Popis: | Cardiovascular diseases represent important complications in rheumatoid arthritis (RA) patients, generated by an accelerated atherosclerosis. The aim of this study is represented by the assessment of the correlations between serum levels of vitamin D, disease activity, and endothelial dysfunction in patients with early RA. Material and Methods. The study was performed on a group of 35 patients with early RA and 35 healthy subjects matched for age and gender, as controls. In all studied subjects, the following were determined: inflammatory markers, insulin resistance, vitamin D levels, and endothelial dysfunction. Statistical analysis were performed using the Student’s t-test and the Pearson’s test. p values of less than 0.05 were considered statistically significant. Results. The group of patients with RA patients presented inflammation, low levels of vitamin D, elevated insulin resistance, and reduced flow-mediated vasodilation, statistically significant compared to the control group (p<0.00001). Significant inverse correlations between the levels of 25(OH) vitamin D and DAS28, respective insulin resistance, and significant positive correlation between 25(OH) vitamin D and endothelial function were demonstrated. Conclusion. In early RA patients with moderate and high disease activity, low serum levels of vitamin D were associated with disease activity, increased insulin resistance, and endothelial dysfunction. |
| Databáze: | OpenAIRE |
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